Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy

S Siddamurthi, G Gutti, S Jana, A Kumar… - Future medicinal …, 2020 - Taylor & Francis
Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in
both advanced and emerging countries. Although, ample drugs are accessible in the market …

[HTML][HTML] Journey of anthraquinones as anticancer agents–a systematic review of recent literature

MS Malik, RI Alsantali, RS Jassas, AA Alsimaree… - RSC …, 2021 - pubs.rsc.org
Anthraquinones are privileged chemical scaffolds that have been used for centuries in
various therapeutic applications. The anthraquinone moiety forms the core of various …

Novel anthraquinone compounds as anticancer agents and their potential mechanism

W Tian, C Wang, D Li, H Hou - Future medicinal chemistry, 2020 - Taylor & Francis
Anthraquinones exhibit a unique anticancer activity. Since their discovery, medicinal
chemists have made several structural modifications, resulting in the design and synthesis of …

Advances in the discovery of anthraquinone-based anticancer agents

AS Tikhomirov, AA Shtil… - Recent patents on anti …, 2018 - ingentaconnect.com
Background: The anthracene-9, 10-dione (anthraquinone) derivatives represent an
exceptionally valuable class in anticancer drug development. An outstanding antitumor …

Alkylating agents, the road less traversed, changing anticancer therapy

D Karati, KR Mahadik, P Trivedi… - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
Cancer is considered one of the gruelling challenges and poses a grave health hazard
across the globe. According to the International Agency for Research on Cancer (IARC) …

A mode of action study of cationic anthraquinone analogs: A new class of highly potent anticancer agents

JP Shrestha, YP Subedi, L Chen, CWT Chang - MedChemComm, 2015 - pubs.rsc.org
Previously, we reported the synthesis and structure–activity relationship (SAR) study of a
series of novel 4, 9-dioxo-4, 9-dihydro-1H-naphtho [2, 3-d][1, 2, 3] triazol-3-ium salts, which …

[HTML][HTML] The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers

Q Zhang, WW Chen, X Sun, D Qian… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Cancers are generally recognized as the leading cause of death and a predominant barrier
to prolonging life expectancy in both developed and developing countries. Emodin is a …

Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules

S Majhi - Physical Sciences Reviews, 2023 - degruyter.com
Cancer is the uncontrolled growth and development of abnormal cells which is a major
cause of death in both advanced and emerging countries. Although currently chemotherapy …

An overview of privileged scaffold: quinolines and isoquinolines in medicinal chemistry as anticancer agents

Y Mao, K Soni, C Sangani, Y Yao - Current Topics in Medicinal …, 2020 - ingentaconnect.com
Cancer is one of the most difficult diseases and causes of death for many decades. Many
pieces of research are continuously going on to get a solution for cancer. Quinoline and …

[HTML][HTML] Insights into the computer-aided drug design and discovery based on anthraquinone scaffold for cancer treatment: A protocol for systematic review

HM Chua, S Moshawih, HP Goh, LC Ming, N Kifli - Plos one, 2023 - journals.plos.org
There is still unmet medical need in cancer treatment mainly due to drug resistance and
adverse drug events. Therefore, the search for better drugs is essential. Computer-aided …