For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

Recent data highlight the role of the proximal tubule (PT) in reabsorbing, processing, and
transcytosing urinary albumin from the glomerular filtrate. Innovative techniques and …

Evidence from multiple studies supports the concept that both glomerular filtration and
proximal tubule (PT) reclamation affect urinary albumin excretion rate. To better understand …

The origin of albuminuria remains controversial owing to difficulties in quantifying the actual
amount of albumin filtered by the kidney. Here we use fluorescently labeled albumin …

Proximal tubule protein uptake is mediated by 2 receptors, megalin and cubilin. These
receptors rescue a variety of filtered ligands, including biomarkers, essential vitamins, and …

The mechanism of albuminuria is perhaps one of the most complex yet important questions
in renal physiology today. Recent studies have directly demonstrated that the normal …

Proteinuria is a prognostic indicator of progressive kidney disease and poor cardiovascular
outcomes. Abnormally filtered bioactive macromolecules interact with proximal tubular …

Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal
tubule. This process involves two interacting receptors, megalin and cubilin, which form a …

▪ Abstract Albumin is the most abundant protein in serum and contributes to the maintenance
of oncotic pressure as well as to transport of hydrophobic molecules. Although albumin is a …

Different laboratories recently reported incongruous results describing the quantification of
albumin filtration using two-photon microscopy. We investigated the factors that influence the …