[HTML][HTML] Identification of key molecules in COVID-19 patients significantly correlated with clinical outcomes by analyzing transcriptomic data

Z Dong, Q Yan, W Cao, Z Liu, X Wang - Frontiers in immunology, 2022 - frontiersin.org
Background Although several key molecules have been identified to modulate SARS-CoV-2
invasion of human host cells, the molecules correlated with outcomes in COVID-19 caused …

[HTML][HTML] Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning …

MN Hoque, MMH Sarkar, MA Khan… - Frontiers in …, 2022 - frontiersin.org
The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2), has created an urgent global situation. Therefore, it is necessary to identify …

[HTML][HTML] Transcriptomic signatures of airway epithelium infected with SARS-CoV-2: a balance between anti-infection and virus load

L Meng, H Qin, J Zhao, S He, Q Wei, Z Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
COVID-19 pneumonia requires effective medical therapies. However, it is a challenge to find
therapeutic drugs that not only inhibit viral replication, but also inhibit the accompanying …

An integrative analysis identifying transcriptional features and key genes involved in COVID-19

G Li, J Wang, X He, L Zhang, Q Ran, A Xiong, D Wu… - …, 2020 - Future Medicine
Aim: To elucidate the transcriptional characteristics of COVID-19. Materials & methods: We
utilized an integrative approach to comprehensively analyze the transcriptional features of …

Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism

M Policard, S Jain, S Rego, S Dakshanamurthy - Virus Research, 2021 - Elsevier
The spread of SARS-CoV-2 and the increasing mortality rates of COVID-19 create an urgent
need for treatments, which are currently lacking. Although vaccines have been approved by …

[HTML][HTML] Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysis

S Maleknia, MJ Tavassolifar, F Mottaghitalab… - Molecular …, 2022 - Springer
Background Regardless of improvements in controlling the COVID-19 pandemic, the lack of
comprehensive insight into SARS-COV-2 pathogenesis is still a sophisticated challenge. In …

[HTML][HTML] Transcriptomic signature differences between SARS-CoV-2 and influenza virus infected patients

S Bibert, N Guex, J Lourenco, T Brahier… - Frontiers in …, 2021 - frontiersin.org
The reason why most individuals with COVID-19 have relatively limited symptoms while
other develop respiratory distress with life-threatening complications remains unknown …

[HTML][HTML] Inflammation and antiviral immune response associated with severe progression of COVID-19

Q Zhang, Y Meng, K Wang, X Zhang, W Chen… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease-2019 (COVID-19) is a novel respiratory disease induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …

[HTML][HTML] Single-cell RNA-seq public data reveal the gene regulatory network landscape of respiratory epithelial and peripheral immune cells in COVID-19 patients

L Zhang, H Nishi, K Kinoshita - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Infection with SARS-CoV-2 leads to coronavirus disease 2019 (COVID-19),
which can result in acute respiratory distress syndrome and multiple organ failure. However …

[HTML][HTML] Molecular signatures in the progression of COVID-19 severity

R De, RK Azad - Scientific Reports, 2022 - nature.com
SARS-CoV-2 is the causative agent of COVID-19 that has infected over 642 million and
killed over 6.6 million people around the globe. Underlying a wide range of clinical …