Biological therapies in inflammatory bowel disease: Beyond anti-TNF therapies

KH Katsanos, K Papamichael, JD Feuerstein… - Clinical …, 2019 - Elsevier
The pharmacological management of inflammatory bowel disease (IBD) over the last two
decades has transitioned from reliance on aminosalycilates, corticosteroids and …

Considerations, challenges and future of anti-TNF therapy in treating inflammatory bowel disease

L Pouillon, P Bossuyt… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Crohn's disease (CD) and ulcerative colitis (UC) are chronic disabling
conditions. Monoclonal antibody therapy directed against tumor necrosis factor-alpha (anti …

Biologic therapies in inflammatory bowel disease

LB Cohen, RM Nanau, F Delzor, MG Neuman - Translational Research, 2014 - Elsevier
Inflammatory bowel disease, including its 2 entities ulcerative colitis and Crohn's disease, is
a chronic medical condition characterized by the destructive inflammation of the intestinal …

[HTML][HTML] Inflammatory bowel disease: updates on molecular targets for biologics

KH Katsanos, KA Papadakis - Gut and Liver, 2017 - ncbi.nlm.nih.gov
Therapy for inflammatory bowel disease (IBD) has changed, with several new agents being
evaluated. The era of anti-tumor necrosis factor (anti-TNF) antibody therapy saw remarkable …

A State-of-the-Art Review of New and Emerging Therapies for the Treatment of IBD

KO Chudy-Onwugaje, KE Christian… - Inflammatory bowel …, 2019 - academic.oup.com
Over the last 2 decades, novel therapies targeting several immune pathways have been
developed for the treatment of patients with inflammatory bowel disease (IBD). Although anti …

[HTML][HTML] Pathogenesis of inflammatory bowel disease and recent advances in biologic therapies

DH Kim, JH Cheon - Immune network, 2017 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an
unknown etiology. IBD is composed of two different disease entities: Crohn's disease (CD) …

Inflammatory bowel disease: towards a personalized medicine

M Flamant, X Roblin - Therapeutic advances in …, 2018 - journals.sagepub.com
The management of inflammatory bowel disease (IBD) has been transformed over the last
two decades by the arrival of tumor necrosis factor (TNF) antagonist agents. Recently …

Current directions of biologic therapies in inflammatory bowel disease

C Reenaers, E Louis… - Therapeutic advances in …, 2010 - journals.sagepub.com
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases
which can be difficult to control with conventional therapies. A greater understanding of their …

Overall and comparative safety of biologic and immunosuppressive therapy in inflammatory bowel diseases

A Holmer, S Singh - Expert review of clinical immunology, 2019 - Taylor & Francis
Introduction: Efficacy and safety are key aspects when choosing therapies for patients with
inflammatory bowel diseases (IBD). While several randomized trials and indirect …

Biologics in inflammatory bowel disease: what are the data?

J Côté-Daigneault, M Bouin, R Lahaie… - United European …, 2015 - journals.sagepub.com
Background Over the last decade, biologics have gained an important place for the
treatment of moderate to severe inflammatory bowel disease (IBD), and many randomized …