Highlights•Inflammation is a physiological process which restores tissue homeostasis.•
Unresolved inflammation can contribute to the pathogenesis of chronic inflammatory …

Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

Abstract Treatment of inflammatory diseases today is largely based on interrupting the
synthesis or action of mediators that drive the host's response to injury. Non-steroidal anti …

An effective resolution program may be able to prevent the progression from non-resolving
acute inflammation to persistent chronic inflammation. It has now become evident that …

Dysregulated inflammation is a central pathological process in diverse disease states.
Traditionally, therapeutic approaches have sought to modulate the pro-or anti-inflammatory …

Current medicines for the clinical management of inflammatory diseases act by inhibiting
specific enzymes or antagonising specific receptors or blocking their ligands. In the past …

A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28,
2006, organized by DW Gilroy and SD Brain for the British Pharmacology Society. We …

It is becoming clear that resolution of acute inflammation is under strict checkpoint control by
endogenous pro-resolution factors. It is these factors and mechanisms inherent in resolution …

Acute inflammation normally resolves by mechanisms that have remained somewhat
elusive. Emerging evidence now suggests that an active, coordinated program of resolution …

Much progress has been made in elucidating the mechanisms regulating the induction and
progression of inflammatory diseases. More recently, however, it has become apparent that …