Pontospinal noradrenergic neurons are thought to form part of a descending endogenous
analgesic system that exerts inhibitory influences on spinal nociception. Using optogenetic …

Noradrenergic neurons of the brainstem extend projections throughout the neuraxis to
modulate a wide range of processes including attention, arousal, autonomic control and …

Pontospinal noradrenergic neurons form a component of an endogenous analgesic system
and represent a potential therapeutic target. We tested the principle that genetic …

Brainstem to spinal cord noradrenergic pathways include a locus coeruleus origin projection
and diffuse noxious inhibitory controls. While both pathways are traditionally viewed as …

1. Brain regions that inhibit nociception can be activated by various environmental stimuli,
including prolonged noxious stimuli. The present study tested the effect of such a prolonged …

Spinally projecting serotonergic neurons play a key role in controlling pain sensitivity and
can either increase or decrease nociception depending on physiological context. It is …

1. Extracellular recordings were made from single superior colliculus neurons in urethane-
anesthetized rats in response to mechanical and/or thermal stimulation of the skin. In …

The aim of this study was to further understand the central processing of inputs arising from
unmyelinated and myelinated nociceptors by (i) determining the response characteristics of …

The CNS houses naturally occurring pathways that project from the brain to modulate spinal
neuronal activity. The noradrenergic locus coeruleus (the A6 nucleus) originates such a …

Nociceptive information is relayed through the spinal cord dorsal horn, a critical area in
sensory processing. The neuronal circuits in this region that underpin sensory perception …