The locus coeruleus (LC) projects throughout the brain and spinal cord and is the major
source of central noradrenaline. It remains unclear whether the LC acts functionally as a …

Current theories of neuropathic hypersensitivity include an imbalance of supraspinal
inhibition and facilitation. Our overall hypothesis is that the locus coeruleus (LC), classically …

Pain thresholds are, in part, set as a function of emotional and internal states by descending
modulation of nociceptive transmission in the spinal cord. Neurons of the rostral …

The amygdala plays a critical role in the emotional-affective component of pain and pain
modulation. The central nucleus of amygdala (CeA) serves major output functions and has …

A total of 51 dorsal horn units responsive to heat were isolated and their receptive fields
characterized (ie, response properties and adequate stimuli determined) in pentobarbital …

Pain perception is strongly influenced by descending pathways from “higher” brain centers
that regulate the activity of spinal circuits. In addition to the extensively studied descending …

Neuropathic pain is a debilitating condition that is often refractory to treatment. The network
of neural substrates for pain transmission and control within the brain is complex and …

Recordings were made from single SI cortical neurons in the anesthetized macaque
monkey. Each isolated cortical neuron was tested for responses to a standard series of …

The spinal dorsal horn receives a dense innervation of noradrenaline‐containing fibers that
originate from pontine neurons in the A5, locus coeruleus (LC), and A7 cell groups. These …

The process of pain perception begins in the periphery by activation of nociceptors. From
here nociceptive signals are conveyed via the dorsal horn of the spinal cord to multiple brain …