1. In anesthetized rats, recordings were made within the medullary subnucleus reticularis
dorsalis (SRD) from neurons that exhibited convergence of nociceptive inputs from the entire …

In this study, we single recorded unit activity at the ventromedial medulla (VMM) level in the
awake, freely moving rat. In agreement with previous work under the same conditions, we …

In addition to the canonical spino-thalamo-cortical pathway, lines of recently accumulated
anatomical and physiological evidence suggest that projections originating in nociception …

Intense stress and fear have long been known to give rise to a suppression of pain termed
“stress-induced analgesia”, mediated by brainstem pain-modulating circuitry, including pain …

Background Optogenetic tools enable cell selective and temporally precise control of
neuronal activity; yet, difficulties in delivering sufficient light to the spinal cord of freely …

Noxious heat applied to the footpad evokes the expression offos protein-like
immunoreactivity in the rat spinal cord lumbar dorsal horn. Electrical stimulation in the …

Painful stimuli evoke a mixture of sensations, negative emotions and behaviors. These
myriad effects are thought to be produced by parallel ascending circuits working in …

Cumulative evidence from both humans and animals suggests that the anterior cingulate
cortex (ACC) is important for pain-related perception, and thus a likely target for pain relief …

The midbrain periaqueductal gray (PAG) and the rostral ventromedial medulla (RVM) are
important links in a neuronal network that modulates nociceptive transmission. In the RVM, 2 …

Nociceptive and non-nociceptive input to the dorsal raphe nucleus (DR) and to the
surroundings periaqueductal grey (PAG) was studied in chloralose-anaesthetized rats …