Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury

JD Carlson, JJ Maire, ME Martenson… - Journal of …, 2007 - Soc Neuroscience
Nerve injury can lead to mechanical hypersensitivity in both humans and animal models,
such that innocuous touch produces pain. Recent functional studies have demonstrated a …

Motor cortex-periaqueductal gray-spinal cord neuronal circuitry may involve in modulation of nociception: a virally mediated transsynaptic tracing study in spinally …

DW Ye, C Liu, TT Liu, XB Tian, HB Xiang - PLoS One, 2014 - journals.plos.org
Several studies have shown that motor cortex stimulation provided pain relief by motor
cortex plasticity and activating descending inhibitory pain control systems. Recent evidence …

Light-evoked somatosensory perception of transgenic rats that express channelrhodopsin-2 in dorsal root ganglion cells

ZG Ji, S Ito, T Honjoh, H Ohta, T Ishizuka, Y Fukazawa… - PloS one, 2012 - journals.plos.org
In vertebrate somatosensory systems, each mode of touch-pressure, temperature or pain is
sensed by sensory endings of different dorsal root ganglion (DRG) neurons, which …

Physiological properties of mouse skin sensory neurons recorded intracellularly in vivo: temperature effects on somal membrane properties

MD Boada, CJ Woodbury - Journal of neurophysiology, 2007 - journals.physiology.org
Recent combined analyses of the structural, functional, and molecular attributes of individual
skin sensory neurons using semi-intact in vitro preparations from mice have provided a …

Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons

T Kirschstein, D Büsselberg, RD Treede - Neuroscience letters, 1997 - Elsevier
Noxious heat is able to activate heat-sensitive nociceptors in the skin very rapidly, but little is
known about the mechanisms by which heat is transduced. We used the whole-cell patch …

Neuronal activity in medullary dorsal horn of awake monkeys trained in a thermal discrimination task. I. Responses to innocuous and noxious thermal stimuli.

DS Hoffman, R Dubner, RL Hayes… - Journal of …, 1981 - journals.physiology.org
2. Similar to medullary dorsal horn neurons in anesthetized monkeys, nociceptive neurons
in the awake monkey could be classified as wide dynamic range (WDR) or nociceptive …

Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex

AA Calejesan, SJ Kim, M Zhuo - European Journal of Pain, 2000 - Elsevier
It is well documented that the descending endogenous analgesia system, including the
periaqueductal gray (PAG) and the rostral ventral medulla (RVM), play an important role in …

Differential cerebellar activation related to perceived pain intensity during noxious thermal stimulation in humans: a functional magnetic resonance imaging study

C Helmchen, C Mohr, C Erdmann, D Petersen… - Neuroscience …, 2003 - Elsevier
Little is known about the cerebellar involvement in pain processing in spite of the fact that
the cerebellum probably plays a crucial role in pain-related behavior. Using functional …

Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain

SE Burgess, LR Gardell, MH Ossipov… - Journal of …, 2002 - Soc Neuroscience
Although injury-induced afferent discharge declines significantly over time, experimental
neuropathic pain persists unchanged for long periods. These observations suggest that …

Neural coding of nociceptive stimuli—from rat spinal neurones to human perception

S Sikandar, I Ronga, GD Iannetti, AH Dickenson - Pain, 2013 - journals.lww.com
Neural coding of nociceptive stimuli—from rat spinal neurone... : PAIN Neural coding of
nociceptive stimuli—from rat spinal neurones to human perception : PAIN International …