MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive
function. Variation in the sequence of MTHFR has been implicated in subfertility, but …

BACKGROUND: There is concern that IVF could compromise normal imprinting and
methylation of DNA. Methylenetetrahydrofolate reductase (MTHFR) regulates the flow of folic …

The aim of this study was to investigate the association between MTHFR gene
polymorphisms and IVF outcomes in Brazilian women undergoing assisted reproduction …

Background Methylenetetrahydrofolate reductase (MTHFR) converts 5, 10-methylene
tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles …

Abstract BACKGROUND Polymorphisms C677T and A1298C of the MTHFR gene have
been implicated in fetal viability. In this study, we determined the allele and genotype …

Introduction Aim of the study was to evaluate the effect of methylenetetrahydrofolate
reductase (MTHFR) polymorphisms on pregnancy outcome. Materials and Methods A total …

Background The prevalence of genotypes of the 677C> T polymorphism for the MTHFR
gene varies among humans. In previous studies, we found changes in the genotypic …

Purpose MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-
nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in …

Abstract Purpose Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-
nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5 …

Low maternal folate or vitamin B12 status has been implicated in numerous pregnancy
complications including spontaneous abortion. The primary aim of this study was to test a …