Background There is a need to identify clinically meaningful non-abstinent endpoints for
cocaine use disorder (CUD) clinical trials. In this study, we sought to replicate and extend …

Abstract Background Quantity (Q), frequency (F), and duration (D) of cocaine use during a
person's heaviest use period are important aspects of cocaine use patterns that associated …

AIMS: To conduct a systematic review of mortality among cohort studies of cocaine users.
METHODS: Three electronic databases were searched (EMBASE, Medline and PsychINFO); …

The current literature does not strongly support any individual MAT for CUD. Psychosocial
interventions, namely contingency management, have the most evidence for treatment of …

Background The severity of substance use disorder (SUD) is currently defined by the sum of
DSM-5 criteria. However, little is known about the validity of this framework or the role of …

Background Comorbid substance use disorders (SUDs) among people with opioid use
disorder (OUD) contribute to poor clinical outcomes, including overdose and mortality. We …

Background Currently, there are no accepted FDA-approved pharmacotherapies for cocaine
use disorder, though numerous medications have been tested in clinical trials. We …

Importance In the US and the United Kingdom, cocaine use is the second leading cause of
illicit drug overdose death. Psychosocial treatments for cocaine use disorder are limited, and …

Background and Objectives Rates of medical illnesses may be higher among individuals
with substance use disorders, complicating their care. This study aimed to expand the …

Objective Cocaine dependence first appeared as a diagnostic category in 1987 with the
publication of DSM‐III‐R. While the temporal sequencing of alcohol symptoms has a long …