Surveillance studies are required to estimate the impact of pneumococcal vaccination in
both children and the elderly across Europe. The World Health Organization (WHO) …

Quantitation of specific IgG to polysaccharides (serotypes) of Streptococcus pneumoniae
provides the basis for evaluating vaccine efficacy. Different enzyme-linked immunosorbent …

We describe the optimization and application of a multiplex bead-based assay (Luminex) to
quantify antibodies against polysaccharides of 13 pneumococcal serotypes. In the optimized …

The multiplexed immunoassay (MIA) is an automated, monoclonal antibody-based
serotyping assay that uses culture lysates of Streptococcus pneumoniae. This study …

National surveillance of pneumococcal disease at the serotype level is essential to assess
the effectiveness of vaccination programmes. We previously developed a highly sensitive …

Pneumococcal antibodies represent the acquisition of natural immunity. Determination of
pneumococcal antibodies is an important screening tool for immunodeficiencies. Our study …

Serum IgG levels specific for Streptococcus pneumoniae are currently quantified using the
ELISA. However, this method has significant limitations in that a separate test is required for …

Streptococcus pneumoniae is a major cause of community-acquired pneumonia (CAP) in
young children, older adults, and those with immunocompromised status. Since the …

Clin Microbiol Infect 2011; 17:(Suppl. 3) 1–13 Abstract In view of the increasing use of
pneumococcal vaccines, especially in the developing world, there is a need for appropriate …

The measurement of serotype-specific anti-capsular polysaccharide antibodies remains the
mainstay of pneumococcal (Pn) vaccine evaluation. New methods that allow the …