The impact of a short‐term high‐fat diet on mitochondrial respiration, reactive oxygen species production, and dynamics in oxidative and glycolytic skeletal muscles of …

JP Leduc‐Gaudet, O Reynaud, F Chabot… - Physiological …, 2018 - Wiley Online Library
Multiple aspects of mitochondrial function and dynamics remain poorly studied in the
skeletal muscle of pediatric models in response to a short‐term high‐fat diet (HFD). This …

Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults

SJ Choi, DC Files, T Zhang, ZM Wang… - … Series A: Biomedical …, 2016 - academic.oup.com
Background. Evidence implicates the amount and location of fat in aging-related loss of
muscle function; however, whether intramyocellular lipids affect muscle contractile capacity …

Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice

J de Wilde, R Mohren, S van den Berg… - Physiological …, 2008 - journals.physiology.org
The prevalence of the metabolic syndrome (MS) is rapidly increasing all over the world.
Consequently, there is an urgent need for more effective intervention strategies. Both animal …

Fatty acid profile of skeletal muscle phospholipid is altered in mdx mice and is predictive of disease markers

MA Tuazon, GC Henderson - Metabolism, 2012 - Elsevier
The mdx mouse is a model for Duchenne muscular dystrophy. The fatty acid (FA)
composition in dystrophic muscle could potentially impact the disease severity. We tested FA …

Dietary enrichment with fish oil prevents high fat-induced metabolic dysfunction in skeletal muscle in mice

LK Philp, LK Heilbronn, A Janovska, GA Wittert - PLoS One, 2015 - journals.plos.org
High saturated fat (HF-S) diets increase intramyocellular lipid, an effect ameliorated by
omega-3 fatty acids in vitro and in vivo, though little is known about sex-and muscle fiber …

Variability in myosteatosis and insulin resistance induced by high‐fat diet in mouse skeletal muscles

M Collino, R Mastrocola, D Nigro… - BioMed research …, 2014 - Wiley Online Library
Nutrient overload leads to impaired muscle oxidative capacity and insulin sensitivity.
However, comparative analyses of the effects of dietary manipulation on skeletal muscles …

Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice

S Timmers, J De Vogel-Van Den Bosch, N De Wit… - Nutrition & …, 2011 - nature.com
Objective: In conditions of continuous high-fat (HF) intake, the degree of saturation of the
fatty acids (FAs) in the diet might have a crucial role in the onset of obesity and its metabolic …

Exercise increases and browns muscle lipid in high-fat diet-fed mice

TL Morton, K Galior, C McGrath, X Wu, G Uzer… - Frontiers in …, 2016 - frontiersin.org
Muscle lipid increases with high-fat feeding and diabetes. In trained athletes, increased
muscle lipid is not associated with insulin resistance, a phenomenon known as the athlete's …

Exercise training prevents skeletal muscle plasma membrane cholesterol accumulation, cortical actin filament loss, and insulin resistance in C57 BL/6J mice fed a …

AG Ambery, L Tackett, BA Penque… - Physiological …, 2017 - Wiley Online Library
Insulin action and glucose disposal are enhanced by exercise, yet the mechanisms involved
remain imperfectly understood. While the causes of skeletal muscle insulin resistance also …

Intramyocellular lipid content and molecular adaptations in response to a 1‐week high‐fat diet

VB Schrauwen‐Hinderling, ME Kooi… - Obesity …, 2005 - Wiley Online Library
Objective: To investigate molecular adaptations that accompany the elevation of
intramyocellular lipid (IMCL) content on a high‐fat (HF) diet for 1 week. Research Methods …