Apoptosis and autophagy are critical in normal skeletal muscle homeostasis; however,
dysregulation can lead to muscle atrophy and dysfunction. Lipotoxicity and/or lipid …

The purpose of this work is to study the influence of aging, training, and food restriction on
skeletal muscle mass and fiber number. Male Fischer 344 rats (n= 49) at 3 mo postpartum …

Background: The metabolic syndrome is associated with sarcopenia. Decreased serum
levels of Vitamin D (VitD) and insulin-like growth factor (IGF)-1 and their mutual relationship …

Excess lipid accumulation resulting from an elevated supply of plasma fatty acids is linked to
the pathogenesis of the metabolic syndrome and heart disease. The term 'lipotoxicity'was …

The decline in muscle function is associated with an age-related decrease in muscle mass
and an age-related decline in strength. However, decreased strength is not solely due to …

We previously reported that both the high-carbohydrate diet (HCD) and high-fat diet (HFD)
given for two months promote lipid deposition and inflammation in the liver and brain of …

The effect of muscle fiber type and maturation on intramyocellular lipid (IMCL) content and
its relationship to insulin resistance was investigated. Intramyocellular lipid content in slow …

The obesogenic effect of a high-fat (HF) diet is counterbalanced by stimulation of energy
expenditure and lipid oxidation in response to a meal. The aim of this study was to reveal …

Skeletal muscle utilizes both free fatty acids (FFAs) and glucose that circulate in the blood
stream. When blood glucose levels acutely increase, insulin stimulates muscle glucose …

Background Lipid hydroperoxides (LOOH) have been implicated in skeletal muscle atrophy
with age and disuse. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), an enzyme of …