Disrupting functional protein homeostasis is an established therapeutic strategy for certain
tumors. Ongoing studies are evaluating autophagy inhibition for overcoming …

Accumulating evidence indicates that therapies designed to trigger apoptosis in tumor cells
cause mitochondrial depolarization, nuclear damage, and the accumulation of misfolded …

Macroautophagy (autophagy hereafter) is a process that collects cytoplasmic components,
particularly mitochondria, and degrades them in lysosomes. In mammalian systems, basal …

Autophagy is a major contributor to anti-cancer therapy resistance. Many efforts have been
made to understand and overcome autophagy-mediated therapy resistance, but these …

Autophagy is a major protein degradation pathway capable of upholding cellular
metabolism under nutrient limiting conditions, making it a valuable resource to highly …

Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting
in basal or stress-induced turnover of cell components that provide energy and …

Autophagy is an ancient cell survival pathway that allows cells to recoup ATP and essential
building blocks for biosynthesis when they are starved of nutrients or when they are exposed …

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous
proteins and organelles. The recycling of these intracellular constituents also serves as an …

Pancreatic ductal adenocarcinomas are an extremely aggressive and devastating type of
cancer with high mortality. Given the dense stroma and poor vascularization, accessibility to …

Autophagy is a highly conserved catabolic and energy-generating process that facilitates the
degradation of damaged organelles or intracellular components, providing cells with …