All living organisms are continuously exposed to threatening pathogens that can attack and
invade them. For this reason, the host developed a series of defence mechanisms in order to …

Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes,
proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial …

Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes,
proinflammatory intracellular complexes, regulate various steps of infection. Lung epithelial …

The nucleotide-binding domain (NOD)-, leucine-rich repeat (LRR)-, and pyrin domain (PYD)-
containing protein 3, NLRP3, is a multiprotein complex belonging to the innate immune …

NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-containing 6 (Nlrp6) is
a member of the NLR (nucleotide-oligomerization domain-like receptor) family that patrols …

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with
severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 …

NLRP1, while the first inflammasome described, has only recently begun to gain significant
attention in disease pathology, inflammation research, and potentially, as a therapeutic …

The last two years have shown many political and scientific debates during the current
Coronavirus Disease 2019 (COVID-19) pandemic [1]. Hydroxychloroquine, an antimalarial …

NLRP3 is one of the best characterized innate immune cytosolic sensor. As part of the innate
immune response, the NLRP3 inflammasome detects a wide range of danger signals such …

Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …