Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system
pathologically characterized by lesions of infiltrating macrophages and T cells. Multiple lines …

Background Multiple sclerosis (MS) is a complex autoimmune disorder characterized by
neurologic dysfunction. The symptoms worsen as the disease progresses to the relapsing …

Multiple sclerosis (MS) has long been considered a CD4 T-cell disease, primarily because
of the findings that the strongest genetic risk for MS is the major histocompatibility complex …

T lymphocytes play a central role in the pathogenesis of multiple sclerosis (MS)(Zhang et al.,
1992). Both CD4+ and CD8+ T cells have been demonstrated in MS lesions, with CD4+ T …

Regulatory T Cells in Multiple Sclerosis Regulatory T cells suppress inflammation and are
defective in autoimmune diseases. A recent study provides new insight into how these cells …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
characterized by focal demyelination patches associated with inflammatory infiltrates …

Multiple exogenous signals received from cell surface molecules or cytokines play a
significant role in altering the host immune response. In chronic autoimmune‐mediated …

Autoimmune T cells play a key role as regulators and effectors of autoimmune disease. In
multiple sclerosis (MS), activated T cells specific for myelin components or other locally …

Introduction Multiple sclerosis (MS) is a complex genetic disease characterized by chronic
inflammation of the central nervous system (CNS). The pathology of MS is largely attributed …

The cause of multiple sclerosis (MS) is unknown, but an immunopathological process with
both endogenous and exogenous factors contributing to disease seems likely. Considerable …