[HTML][HTML] A Novel Vaccine Delivery Model of the Apicomplexan Eimeria tenella Expressing Eimeria maxima Antigen Protects Chickens against Infection of the Two …

X Tang, X Liu, G Yin, J Suo, G Tao, S Zhang… - Frontiers in …, 2018 - frontiersin.org
Vaccine delivery is critical in antigen discovery and vaccine efficacy and safety. The diversity
of infectious diseases in humans and livestock has required the development of varied …

[HTML][HTML] Co-immunization with two recombinant Eimeria tenella lines expressing immunoprotective antigens of E. maxima elicits enhanced protection against E …

X Tang, C Wang, L Liang, D Hu, S Zhang, C Duan… - Parasites & vectors, 2019 - Springer
Background Live anticoccidial vaccines have been a tremendous success for disease
prevention. The establishment of the reverse genetic manipulation platform has enabled the …

[HTML][HTML] Vaccination with transgenic Eimeria tenella expressing Eimeria maxima AMA1 and IMP1 confers partial protection against high-level E. maxima challenge …

I Pastor-Fernández, S Kim, V Marugán-Hernández… - Parasites & …, 2020 - Springer
Background Poultry coccidiosis is a parasitic enteric disease with a highly negative impact
on chicken production. In-feed chemoprophylaxis remains the primary method of control, but …

Transgenic Eimeria tenella expressing profilin of Eimeria maxima elicits enhanced protective immunity and alters gut microbiome of chickens

X Tang, J Suo, C Li, M Du, C Wang, D Hu… - Infection and …, 2018 - Am Soc Microbiol
Coccidiosis is one of the most serious diseases of livestock and birds in the world.
Vaccination with live-parasite anticoccidial vaccines with genetic manipulation improving the …

Development of cross-protective Eimeria-vectored vaccines based on apical membrane antigens

I Pastor-Fernández, S Kim, K Billington… - International Journal for …, 2018 - Elsevier
Recently, the availability of protocols supporting genetic complementation of Eimeria has
raised the prospect of generating transgenic parasite lines which can function as vaccine …

Eimeria species parasites as novel vaccine delivery vectors: anti-Campylobacter jejuni protective immunity induced by Eimeria tenella-delivered CjaA

JD Clark, RD Oakes, K Redhead, CF Crouch… - Vaccine, 2012 - Elsevier
Vaccination of poultry against coccidiosis caused by the Eimeria species is almost entirely
based upon varied formulations of live parasites. The recent development of a series of …

Towards Innovative Design and Application of Recombinant Eimeria as a Vaccine Vector

X Tang, X Liu, X Suo - Infection and Immunity, 2020 - Am Soc Microbiol
Efficient delivery of antigenic cargo to trigger protective immune responses is critical to the
success of vaccination. Genetically engineered microorganisms, including virus, bacteria …

Construction of Eimeria tenella multi-epitope DNA vaccines and their protective efficacies against experimental infection

X Song, L Xu, R Yan, X Huang, X Li - Veterinary immunology and …, 2015 - Elsevier
The search for effective vaccines against chicken coccidiosis remains a challenge because
of the complex organisms with multiple life cycle stages of Eimeria. Combination of T-cell …

Transgenic Eimeria parasite: A potential control strategy for chicken coccidiosis

AJ Fatoba, MA Adeleke - Acta tropica, 2020 - Elsevier
Poultry industry has been very instrumental in curtailing malnutrition and poverty and as
such contributing to economic growth. However, production loss in poultry industry due to …

EMBRYO VACCINATION AGAINST EIMERIA TENELLA AND E. ACERVULINA INFECTIONS USING RECOMBINANT PROTEINS AND CYTOKINE ADJUVANTS

HS Lillehoj, X Ding, RA Dalloul, T Sato… - Journal of …, 2005 - meridian.allenpress.com
Avian coccidiosis is an intestinal disease caused by protozoa of the genus Eimeria. To
investigate the potential of recombinant protein vaccines to control coccidiosis, we cloned 2 …