Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
J Xu, S Liu, X Yang, S Cao, Y Zhou - Life Sciences, 2020 - Elsevier
Abstract Background Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor
microenvironment and are considered to contribute to chemoresistance. PSCs can …
microenvironment and are considered to contribute to chemoresistance. PSCs can …
[HTML][HTML] HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis
Pancreatic cancer (PC) is a deadly cancer with a high mortality rate. The unique
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …
characteristics of PC, including desmoplasia and immunosuppression, have made it difficult …
Targeting the HGF/c-MET pathway in advanced pancreatic cancer: A key element of treatment that limits primary tumour growth and eliminates metastasis
Background Stromal–tumour interactions facilitate pancreatic cancer (PC) progression. The
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
hepatocyte growth factor (HGF)/c-MET pathway is upregulated in PC and mediates the …
Pancreatic stellate cells increase pancreatic cancer cells invasion through the hepatocyte growth factor/c-Met/survivin regulated by P53/P21
XP Yang, SL Liu, JF Xu, SG Cao, Y Li… - Experimental cell research, 2017 - Elsevier
Pancreatic stellate cells (PSCs) are a key cellular component of the pancreatic tumor
microenvironment and are considered to contribute to tumor invasion and metastasis …
microenvironment and are considered to contribute to tumor invasion and metastasis …
Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition
Background Epidermal growth factor receptor (EGFR) is an essential target for cancer
treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic …
treatment. However, EGFR inhibitor erlotinib showed limited clinical benefit in pancreatic …
Pancreatic stellate cells facilitate perineural invasion of pancreatic cancer via HGF/c-Met pathway
L Nan, T Qin, Y Xiao, W Qian, J Li, Z Wang… - Cell …, 2019 - journals.sagepub.com
Pancreatic cancer (PC) is a highly lethal cancer that has a strong ability for invasion and
metastasis, poor prognosis, and a stubbornly high death rate due to late diagnosis and early …
metastasis, poor prognosis, and a stubbornly high death rate due to late diagnosis and early …
[HTML][HTML] Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and …
V Tjomsland, M Aasrum, T Christoffersen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The pancreatic stellate cell (PSC) is the principal cell type of the desmoplastic stroma of
pancreatic ductal adenocarcinoma (PDAC). PSCs interact with cancer cells and influence …
pancreatic ductal adenocarcinoma (PDAC). PSCs interact with cancer cells and influence …
Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α
B Yan, Z Jiang, L Cheng, KE Chen, C Zhou… - Experimental cell …, 2018 - Elsevier
Pancreatic stellate cells (PSCs), a pivotal component of the tumor microenvironment,
contribute to tumor growth and metastasis. PSC-derived factors are essential for triggering …
contribute to tumor growth and metastasis. PSC-derived factors are essential for triggering …
HGF/MET Axis induces tumor secretion of tenascin-C and promotes stromal rewiring in pancreatic cancer
C Modica, M Olivero, F Zuppini, M Milan, C Basilico… - Cancers, 2021 - mdpi.com
Simple Summary It has been previously shown that activation of the MET receptor by its
ligand, the hepatocyte growth factor (HGF), modulates the tumor-stroma cross-talk in models …
ligand, the hepatocyte growth factor (HGF), modulates the tumor-stroma cross-talk in models …
The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell–endothelial cell interactions: antiangiogenic implications in pancreatic cancer
MB Patel, SP Pothula, Z Xu, AK Lee… - …, 2014 - academic.oup.com
Activated cancer-associated human pancreatic stellate cells (CAhPSCs, which produce the
collagenous stroma of pancreatic cancer [PC]) are known to play a major role in PC …
collagenous stroma of pancreatic cancer [PC]) are known to play a major role in PC …