The acidic microenvironments of tumor tissue and cells provide an opportunity for the
development of pH-responsive drug delivery systems in cancer therapy. In this work, we …

A mineral (calcium phosphate, CaP)-reinforced core-shell-corona micelle was evaluated as
a nanocarrier of doxorubicin (DOX) for cancer therapy. The polymer micelles of poly …

In continuing search for effective treatments of cancer, the emerging model aims at efficient
intracellular delivery of therapeutics into tumor cells in order to increase the drug …

In this paper, we facilitated the preparation of uniform calcium carbonate nanospheres and
the encapsulation of anticancer drug (Doxorubicin, Dox) in one step by a facile bio-inspired …

Osteosarcoma is the most common malignancy in the bone. Current chemotherapy offers
limited efficacy with significant side effects, especially for advanced and relapsed …

Zoledronic acid (ZA), a third-generation bisphosphonate, has been extensively used to treat
osteoporosis and cancer bone metastasis and demonstrated to suppress proliferation of …

Breast cancer is the abnormal, uncontrollable proliferation of cells in the breast.
Conventional treatment modalities like chemotherapy induce deteriorating side effects on …

Tumor-targeted drug delivery systems have been increasingly used to improve the
therapeutic efficiency of anticancer drugs and reduce their toxic side effects in vivo. Focused …

Targeted delivery of anticancer drugs is one of the most promising methods for cancer
therapy. However, barriers including complicated procedures, costly preparation, and toxic …

Drug delivery systems are designed to achieve drug therapeutic index and enhance the
efficacy of controlled drug release targeting with specificity and selectivity by successful …