Although experimental autoimmune encephalomyelitis (EAE) is limited in its potency to
reproduce the entirety of clinical and histopathologic features of multiple sclerosis (MS), this …

Autoreactive T cell responses have a crucial role in central nervous system (CNS) diseases
such as multiple sclerosis. Recent data indicate that CNS autoimmunity can be mediated by …

Multiple sclerosis is considered a disease of complex autoimmune etiology, yet there
remains a lack of consensus as to specific immune effector mechanisms. Recent analyses of …

Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis
(EAE) have long been regarded as primarily T helper cell type 1-mediated diseases …

Experimental autoimmune encephalomyelitis (EAE) is a mouse model for multiple sclerosis,
where disease is mediated by autoantigen-specific T cells. Although there is evidence …

Autoreactive CD4+ T cells, which target antigens in central nervous system (CNS) myelin,
are widely believed to play a critical role in the pathogenesis of multiple sclerosis (MS) in …

Experimental autoimmune encephalomyelitis (EAE) is a model of human multiple sclerosis
induced by autoreactive Th cells that mediate tissue inflammation and demyelination in the …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) of putative autoimmune origin. Recent evidence indicates that MS …

A growing body of evidence suggests that autoreactive CD8 T cells contribute to the disease
process in multiple sclerosis (MS). Lymphocytes in MS plaques are biased toward the CD8 …

In EAE/MS, effector molecules are produced as a result of the interaction between T
lymphocytes and antigen-presenting cells and the spectrum of cytokines produced is likely …