A novel type of N-acetylglutamate synthase is involved in the first step of arginine biosynthesis in Corynebacterium glutamicum
Abstract Background Arginine biosynthesis in Corynebacterium glutamicum consists of eight
enzymatic steps, starting with acetylation of glutamate, catalysed by N-acetylglutamate …
enzymatic steps, starting with acetylation of glutamate, catalysed by N-acetylglutamate …
Site-Directed Mutagenesis Studies on the l-Arginine-Binding Sites of Feedback Inhibition in N-Acetyl-l-glutamate Kinase (NAGK) from Corynebacterium glutamicum
M Xu, Z Rao, W Dou, J Jin, Z Xu - Current microbiology, 2012 - Springer
Arginine biosynthesis in Corynebacterium glutamicum proceeds via a pathway that is
controlled by arginine through feedback inhibition of NAGK, the enzyme that converts N …
controlled by arginine through feedback inhibition of NAGK, the enzyme that converts N …
Increased l-arginine production by site-directed mutagenesis of N-acetyl-l-glutamate kinase and proB gene deletion in Corynebacterium crenatum
B Zhang, WAN Fang, YL Qiu, XL Chen, T Li… - Biomedical and …, 2015 - Elsevier
Abstract Objective In Corynebacterium crenatum, the adjacent D311 and D312 of N-acetyl-L-
glutamate kinase (NAGK), as a key rate-limiting enzyme of L-arginine biosynthesis under …
glutamate kinase (NAGK), as a key rate-limiting enzyme of L-arginine biosynthesis under …
Identification of a suppressor gene for the arginine-auxotrophic argJ mutation in Corynebacterium glutamicum
GH Hwang, JY Cho - Journal of Industrial Microbiology and …, 2010 - academic.oup.com
We recently proposed a metabolic engineering strategy for l-ornithine production based on
the hypothesis that an increased intracellular supply of N-acetylglutamate may further …
the hypothesis that an increased intracellular supply of N-acetylglutamate may further …
Controlling the transcription levels of argGH redistributed l-arginine metabolic flux in N-acetylglutamate kinase and ArgR-deregulated Corynebacterium crenatum
Q Zhao, Y Luo, W Dou, X Zhang… - Journal of Industrial …, 2016 - academic.oup.com
Abstract Corynebacterium crenatum SYPA5-5, an l-arginine high-producer obtained through
multiple mutation-screening steps, had been deregulated by the repression of ArgR that …
multiple mutation-screening steps, had been deregulated by the repression of ArgR that …
Mutational analysis to identify the residues essential for the inhibition of N-acetyl glutamate kinase of Corynebacterium glutamicum
Y Huang, H Zhang, H Tian, C Li, S Han, Y Lin… - Applied microbiology …, 2015 - Springer
N-acetyl glutamate kinase (NAGK) is a key enzyme in the synthesis of l-arginine that is
inhibited by its end product l-arginine in Corynebacterium glutamicum (C. glutamicum). In …
inhibited by its end product l-arginine in Corynebacterium glutamicum (C. glutamicum). In …
Surprising arginine biosynthesis: a reappraisal of the enzymology and evolution of the pathway in microorganisms
Y Xu, B Labedan, N Glansdorff - Microbiology and molecular …, 2007 - Am Soc Microbiol
Major aspects of the pathway of de novo arginine biosynthesis via acetylated intermediates
in microorganisms must be revised in light of recent enzymatic and genomic investigations …
in microorganisms must be revised in light of recent enzymatic and genomic investigations …
Genomics and transcriptomics-guided metabolic engineering Corynebacterium glutamicum for L-arginine production
Z Zhao, M Cai, Y Liu, M Hu, F Yang, R Zhu, M Xu… - Bioresource …, 2022 - Elsevier
Abstract l-arginine is a semi-essential amino acid that is broadly used as food additives and
pharmaceutical intermediates. The synthesis of l-arginine is restricted by complex metabolic …
pharmaceutical intermediates. The synthesis of l-arginine is restricted by complex metabolic …
Site-directed mutagenesis and feedback-resistant N-acetyl-L-glutamate kinase (NAGK) increase Corynebacterium crenatum L-arginine production
M Xu, Z Rao, W Dou, J Yang, J Jin, Z Xu - Amino Acids, 2012 - Springer
N-Acetyl-l-glutamate kinase (EC 2.7. 2.8) is first committed in the specific l-arginine pathway
of Corynebacterium sp. A limited increase of l-arginine production for the arg B …
of Corynebacterium sp. A limited increase of l-arginine production for the arg B …
Genes and enzymes of the acetyl cycle of arginine biosynthesis in Corynebacterium glutamicum: enzyme evolution in the early steps of the arginine pathway
V Sakanyan, P Petrosyan, M Lecocq… - …, 1996 - microbiologyresearch.org
A cluster of arginine biosynthetic genes of Corynebacterium glutamicum ATCC 13032,
comprising argJ, argB and argD as well as part of argC and argF, has been cloned by …
comprising argJ, argB and argD as well as part of argC and argF, has been cloned by …
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