Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role
of somatic mutations in both normal and pathological processes. Significantly, cancer …
of somatic mutations in both normal and pathological processes. Significantly, cancer …
Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type
I Franco, HT Helgadottir, A Moggio, M Larsson… - Genome biology, 2019 - Springer
Background The lifelong accumulation of somatic mutations underlies age-related
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …
[HTML][HTML] Age-related somatic mutations in the cancer genome
Aging is associated with an increased risk of cancer, possibly in part because of an age-
related increase in mutations in normal tissues. Due to their extremely low abundance …
related increase in mutations in normal tissues. Due to their extremely low abundance …
Cells with cancer‐associated mutations overtake our tissues as we age
EJ Evans Jr, J DeGregori - Aging and cancer, 2021 - Wiley Online Library
Background To shed light on the earliest events in oncogenesis, there is growing interest in
understanding the mutational landscapes of normal tissues across ages. In the last decade …
understanding the mutational landscapes of normal tissues across ages. In the last decade …
[HTML][HTML] Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations
K Chatsirisupachai, JP de Magalhães - Ageing Research Reviews, 2024 - Elsevier
The accumulation of somatic mutations is a driver of cancer and has long been associated
with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous …
with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous …
The somatic mutation landscape of the human body
PE García-Nieto, AJ Morrison, HB Fraser - Genome biology, 2019 - Springer
Background Somatic mutations in healthy tissues contribute to aging, neurodegeneration,
and cancer initiation, yet they remain largely uncharacterized. Results To gain a better …
and cancer initiation, yet they remain largely uncharacterized. Results To gain a better …
The dynamics of somatic mutagenesis during life in humans
From conception to death, human cells accumulate somatic mutations in their genomes.
These mutations can contribute to the development of cancer and non-malignant diseases …
These mutations can contribute to the development of cancer and non-malignant diseases …
Analysis of cancer genomes reveals basic features of human aging and its role in cancer development
DI Podolskiy, AV Lobanov, GV Kryukov… - Nature …, 2016 - nature.com
Somatic mutations have long been implicated in aging and disease, but their impact on
fitness and function is difficult to assess. Here by analysing human cancer genomes we …
fitness and function is difficult to assess. Here by analysing human cancer genomes we …
Age-related somatic mutation burden in human tissues
P Ren, X Dong, J Vijg - Frontiers in Aging, 2022 - frontiersin.org
The genome of multicellular organisms carries the hereditary information necessary for the
development of all organs and tissues and to maintain function in adulthood. To ensure the …
development of all organs and tissues and to maintain function in adulthood. To ensure the …
Cancer-associated mutations but no cancer: insights into the early steps of carcinogenesis and implications for early cancer detection
Cancer is a disease of aging fueled by the accumulation of somatic mutations. While
mutations in tumors are well characterized, little is known about the early mutational …
mutations in tumors are well characterized, little is known about the early mutational …
相关搜索
- mutational signatures in human cancers
- somatic mutations cancer genome
- cancer genomes human aging
- cancer genomes basic features
- somatic mutations human ageing
- somatic mutations dna sequencing
- implications for early cancer detection
- cell type somatic mutagenesis
- cancer development human aging
- cancer development basic features
- cancer detection early steps