Organ donor shortage is a global problem, and patients die every day waiting for a
transplant. In the field of tissue engineering, a major aim is to grow functional organs and …

The pancreatic islet is a highly vascularized micro-organ, and rapid revascularization
postislet transplantation is important for islet survival and function. However, the various …

Creating artificial organs is a long-standing goal of tissue engineering and regenerative
medicine, providing a potential alternative to organ donation without the complications …

The vasculature is an essential, physiological element in virtually all human tissues.
Formation of perfusable vasculature is therefore crucial for reliable tissue modeling. Three …

The generation of functional microvascular networks is critical for the development of
advanced in vitro models to replicate pathophysiological conditions. Mural cells provide …

From the inception of tissue engineering, tissue vascularization has been one of the greatest
challenges in this field. Our inability to capture the daunting complexity of this natural …

Only a few engineered tissues—skin, cartilage, bladder—have achieved clinical success,
and biomaterials designed to replace more complex organs are still far from commercial …

Vascularization is a major hurdle in complex tissue and organ engineering. Tissues greater
than 200 μm in diameter cannot rely on simple diffusion to obtain nutrients and remove …

Tissue engineering has attracted wide interest as a potential method to alleviate the
shortage of transplantable organs (1). To date, almost all of the successfully engineered …

At the present time, there are many hurdles to overcome in order to create a long-lasting and
engineered tissue for tissue transplant in patients. The challenges include the isolation and …