Phospholipase Cβ (PLCβ) cleaves phosphatidylinositol-4, 5-bisphosphate (PIP2) into the
second messengers inositol-1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG). IP3 …

Phospholipase C (PLC) enzymes convert the membrane phospholipid phosphatidylinositol-
4, 5-bisphosphate (PIP2) into inositol-1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG) …

The receptor‐regulated phospholipase C‐β (PLC‐β) signaling pathway is an important
component in a network of signaling cascades that regulate cell function. PLC‐βsignaling …

Phospholipase Cβ (PLCβ) enzymes are peripheral membrane proteins required for normal
cardiovascular function. PLCβ hydrolyzes phosphatidylinositol 4, 5-bisphosphate, producing …

The phospholipase C (PLC) family of enzymes canonically hydrolyzes the inner plasma
membrane lipid phosphatidylinositol-4, 5-bisphosphate (PIP2) to inositol-1, 4, 5-triphosphate …

Cardiovascular disease is the leading cause of death in the world. The phospholipase C
(PLC) family of enzymes, in particular the PLCε subfamily, are essential for normal …

Phospholipase C-βs (PLCβs) catalyze the hydrolysis of phosphatidylinositol 4, 5–
bisphosphate (PIP 2) into inositoltriphosphate (IP3) and diacylglycerol (DAG). PIP 2 …

Phospholipase C (PLC) enzymes hydrolyze phosphoinositide lipids to inositol phosphates
and diacylglycerol. Direct activation of PLCβ by Gα q and/or Gβγ subunits mediates …

Phospholipase C (PLC) 1 hydrolyzes phosphatidylinositol 4, 5-bisphosphate to generate the
second messengers, inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 …

PLC (phospholipase C) enzymes hydrolyze phosphatidylinositol lipids to generate inositol
phosphates (IPx) and diacylglycerol (DAG). These second messengers stimulate …