Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis …

A Petersen, LG Hansen, N Mirza, C Crocoll… - Bioscience …, 2019 - portlandpress.com
Methylthioalkylmalate synthases catalyse the committing step of amino acid chain
elongation in glucosinolate biosynthesis. As such, this group of enzymes plays an important …

MAM3 catalyzes the formation of all aliphatic glucosinolate chain lengths in Arabidopsis

S Textor, JW De Kraker, B Hause… - Plant …, 2007 - academic.oup.com
Abstract Chain elongated, methionine (Met)-derived glucosinolates are a major class of
secondary metabolites in Arabidopsis (Arabidopsis thaliana). The key enzymatic step in …

[HTML][HTML] Methylthioalkylmalate synthases: genetics, ecology and evolution

M Benderoth, M Pfalz, J Kroymann - Phytochemistry Reviews, 2009 - Springer
Glucosinolates display an enormous amount of structural variation, both within and between
species. This diversity is thought to have evolved in response to challenges imposed on …

From Amino Acid to Glucosinolate Biosynthesis: Protein Sequence Changes in the Evolution of Methylthioalkylmalate Synthase in Arabidopsis

JW De Kraker, J Gershenzon - The Plant Cell, 2011 - academic.oup.com
Methylthioalkylmalate synthase (MAM) catalyzes the committed step in the side chain
elongation of Met, yielding important precursors for glucosinolate biosynthesis in …

Biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana: recombinant expression and characterization of methylthioalkylmalate synthase, the …

S Textor, S Bartram, J Kroymann, KL Falk, A Hick… - Planta, 2004 - Springer
The major class of glucosinolates in Arabidopsis thaliana (L.) Heynh. are biosynthesized
from methionine involving a three-step chain-elongation cycle. Each passage through the …

Molecular basis of the evolution of methylthioalkylmalate synthase and the diversity of methionine-derived glucosinolates

R Kumar, SG Lee, R Augustine, M Reichelt… - The Plant …, 2019 - academic.oup.com
The globally cultivated Brassica species possess diverse aliphatic glucosinolates, which are
important for plant defense and animal nutrition. The committed step in the side chain …

[HTML][HTML] Lineage-specific evolution of Methylthioalkylmalate synthases (MAMs) involved in glucosinolates biosynthesis

J Zhang, X Wang, F Cheng, J Wu, J Liang… - Frontiers in Plant …, 2015 - frontiersin.org
Methylthioalkylmalate synthases (MAMs) encoded by MAM genes are central to the
diversification of the glucosinolates, which are important secondary metabolites in …

Glucosinolate biosynthesis: role of MAM synthase and its perspectives

B Das - Bioscience Reports, 2021 - portlandpress.com
Glucosinolates, synthesized by the glucosinolate biosynthesis pathway, are the secondary
metabolites used as a defence mechanism in the Brassicaceae plants, including …

Expression pattern of the glucosinolate side chain biosynthetic genes MAM1 and MAM3 of Arabidopsis thaliana in different organs and developmental stages

IR Redovniković, S Textor, B Lisnić… - Plant Physiology and …, 2012 - Elsevier
Aliphatic glucosinolates, secondary metabolites known to be involved in plant defence,
make up the majority of the glucosinolate content of Arabidopsis thaliana, and their structural …

Expression of a Brassica Isopropylmalate Synthase Gene in Arabidopsis Perturbs Both Glucosinolate and Amino Acid Metabolism

B Field, C Furniss, A Wilkinson, R Mithen - Plant molecular biology, 2006 - Springer
Isopropylmalate synthase (IPMS) is a key enzyme in the biosynthesis of the essential amino
acid leucine, and thus primary metabolism. In Arabidopsis, the functionally similar enzyme …