Objective The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for dementia
and Alzheimer's disease (AD), but the underlying mechanism for the increased risk is not …

Background Alzheimer's disease (AD) and vascular contributions to cognitive impairment
and dementia (VCID) pathologies coexist in patients with cognitive impairment. Abnormal …

Background: Cerebral small vessel disease (SVD) and neuropsychiatric symptoms (NPS)
independently increase the risk of cognitive decline. While their co-existence has been …

Background: There is growing evidence that vascular risk factors (VRF) contribute to
cognitive decline. Whether their treatment can slow down the progression of Alzheimer …

Objective: To examine the association between brain structural changes and β-amyloid
deposition, and incident dementia in 183 elderly subjects without dementia (mean age 85.5 …

Objective: Growing evidence suggests that vascular risk factors (VRF) contribute to cognitive
decline. The aim of this study was to investigate the impact of VRF on the conversion from …

There is no consensus on which test is more suited to outline the cognitive deficits of
cerebral small vessel disease (cSVD) patients. We explored the ability of eight cognitive …

Objective To examine the effects of baseline Alzheimer disease and cerebrovascular
disease markers on longitudinal default mode network (DMN) and executive control network …

Cerebral small vessel disease (CSVD) refers to a group of pathological processes with
multifarious etiologies that affect the small arteries, arterioles, venules, and capillaries of the …

Background and Objectives The goals of this work were to quantify the independent and
interactive associations of β-amyloid (Aβ) and white matter hyperintensity volume (WMHV), a …