Glabridin alleviates inflammation and nociception in rodents by activating BKCa channels and reducing NO levels

A Parlar, SO Arslan, SA Çam - Biological and Pharmaceutical Bulletin, 2020 - jstage.jst.go.jp
Inflammation, and the pain that accompanies it, is a natural response of the body. The
licorice plant (Glycyrrhiza glabra) have demonstrated anti-inflammatory, anti-edematous …

Anti‐inflammatory and antinociceptive activities of bufalin in rodents

L Wen, Y Huang, X Xie, W Huang, J Yin… - Mediators of …, 2014 - Wiley Online Library
The aims of this study were to evaluate the anti‐inflammatory and analgesic effects of
bufalin, a major component of “Chan‐su.” We used a carrageenan‐induced paw edema …

Glabridin inhibits lipopolysaccharide‐induced activation of a microglial cell line, BV‐2, by blocking NF‐κB and AP‐1

SH Park, JS Kang, YD Yoon, K Lee, KJ Kim… - Phytotherapy …, 2010 - Wiley Online Library
Glabridin, a flavonoid present in licorice root, is known to have antiinflammatory and
cardiovascular protective activities. The present study reports an inhibitory effect of glabridin …

Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis

NE El-Ashmawy, NF Khedr, HA El-Bahrawy… - …, 2018 - Springer
Background Alternative medicine is widely accepted by public and becoming an attractive
approach for treatment of various diseases. Glabridin (Gla), a major flavonoid present in …

Anti-inflammatory and analgesic effect of plumbagin through inhibition of nuclear factor-κB activation

P Luo, YF Wong, L Ge, ZF Zhang, Y Liu, L Liu… - Journal of Pharmacology …, 2010 - ASPET
Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone)(PL) is a naturally occurring yellow
pigment found in the plants of the Plumbaginaceae, Droseraceae, Ancistrocladaceae, and …

Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock

JS Kang, YD Yoon, IJ Cho, MH Han, CW Lee… - … of Pharmacology and …, 2005 - ASPET
(R)-4-(3, 4-Dihydro-8, 8-dimethyl)-2 H, 8 H-benzo [1, 2-b: 3, 4-b′] dipyran-3yl)-1, 3-
benzenediol (glabridin), a flavonoid present in licorice extract, is known to have …

Mechanistic action of linalyl acetate: Acyclic monoterpene isolated from bitter orange leaf as anti-inflammatory, analgesic, antipyretic agent: Role of TNF-α, IL1β, PGE2 …

A Alqahtani, MF Abdelhameed, R Abdou… - Industrial Crops and …, 2023 - Elsevier
The intervention of inflammation disorders with conventional synthetic drugs has several
hazards. Medicinal plants and their byproducts are beneficial in the treatment of …

Naringenin reduces inflammatory pain in mice

FA Pinho-Ribeiro, AC Zarpelon, V Fattori… - …, 2016 - Elsevier
Naringenin is a flavonoid widely consumed by humans that present anti-inflammatory
activity and low toxicity. Recently, the analgesic effect of naringenin has been demonstrated …

Batatasin III, a Constituent of Dendrobium scabrilingue, Improves Murine Pain-like Behaviors with a Favorable CNS Safety Profile

Hasriadi, PWD Wasana, B Sritularak… - Journal of Natural …, 2022 - ACS Publications
Batatasin III is a stilbenoid compound present in a wide variety of Dendrobium species.
Although the pharmacological efficacy of batatasin III has been reported in several disease …

Analgesic and Anti-Inflammatory Activities of the Methanol Extract of Kalanchoe gracilis (L.) DC Stem in Mice

ZR Lai, WH Peng, YL Ho, SC Huang… - The American journal …, 2010 - World Scientific
In this study, we evaluated the analgesic effect of the methanol extract of Kalanchoe gracilis
(MKGS) stem in animal models by inducing writhing response with acetic acid and …