Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic
process. They are mainly caused by impaired neovascularization, neuropathy, and …

Nonhealing chronic wounds on foot are one of the most dreaded complications of diabetes,
and biomedical scaffolds remain an attractive option for repairing or regenerating tissues …

Diabetic wound is hard to heal mainly because of the difficulty in vascularization in the
wound area. Accumulating results have shown that desferrioxamine (DFO) can promote …

Changes in blood vessel formation, especially microvasculature formation, are one of the
most important factors contributing to the poor wound healing capabilities of diabetic …

AIMS: Hypoxia-inducible factor (HIF)-1α plays a pivotal role during the process of wound
healing. Previous studies reported that deferoxamine (DFO) could increase HIF-1α stability …

The hyperglycemia microenvironment of diabetic foot ulcer (DFU) led to impaired
angiogenesis and delayed wound healing. An elevated matrix metalloproteinase (MMP) is …

Dysangiogenesis and chronic inflammation are two critical reasons for diabetic foot ulcers.
Desferrioxamine (DFO) was used clinically in the treatment of diabetic foot ulcers by …

The extracellular matrix (ECM), comprising of hundreds of proteins, mainly collagen,
provides physical, mechanical support for various cells and guides cell behavior as an …

Neovascularization is critical to improve the diabetic microenvironment, deliver abundant
nutrients to the wound and promote wound closure. However, the excess of oxidative stress …

Diabetic foot ulcer (DFU) is often associated with the risk of non-traumatic lower extremity
amputations in diabetic patients. Wound dressing with the active therapeutic agent (s) would …