Diabetic foot ulcer (DFU) is a chronic complication of diabetes. Wound healing in patients
with DFU is generally very slow, with a high recurrence rate even after the ulcer healed. The …

Chronic refractory wounds are one of the most serious complications of diabetes, and the
effects of common treatments are limited. Chiral hydrogel combined with …

Impaired angiogenesis is one of the crucial factors that impede the wound healing process
in diabetic foot ulcers (DFUs). In this study, we found that 20 (S)-protopanaxadiol (PPD), an …

Diabetic foot ulcer is closely associated with peripheral vascular disease. Enhancement of
tissue oxidative stress, reduction of nitric oxide (NO) and angiogenic growth factors, and …

Nanoparticles have higher frequency of being exposed to cells or tissue, and are thus more
likely to gain access into cytoplasm or nuclei to modulate molecular events due to …

Chronic wound, such as skin defect after burn, pressure ulcer, and diabetic foot ulcer is very
difficult to cure. Its pathological process is often accompanied with local temperature rise, pH …

Desferrioxamine (DFO) upregulates HIF-1α and stimulates expression of vascular
endothelial growth factor (VEGF), thereby accelerating neovascularization. As DFO acts …

Wound therapy remains a clinical challenge. Incorporation of growth factors (GFs) into
heparin-functionalized polymer hydrogel is considered as a promising strategy to improve …

Triggering the repair process of diabetic wounds is a huge clinical challenge due to
microbial infection, the reduced migration and proliferation of fibroblasts, decreased …

Diabetic wound healing remains a major challenge due to its vulnerability to bacterial
infection, as well as the less vascularization and prolonged inflammatory phase. In this …