The sensor histidine kinase ArlS is necessary for Staphylococcus aureus to activate ArlR in response to nutrient availability

PK Párraga Solórzano, AC Shupe… - Journal of …, 2021 - Am Soc Microbiol
Staphylococcus aureus is a versatile opportunistic pathogen whose success is driven by its
ability to adapt to diverse environments and host-imposed stresses. Two-component signal …

Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus

AL Cheung, AS Bayer, G Zhang… - FEMS Immunology & …, 2004 - academic.oup.com
Staphylococcus aureus is an opportunistic pathogen. In response to changing host
environments, this bacterium has the capability to switch on selective sets of genes to …

Regulation of the Expression of Cell Wall Stress Stimulon Member Gene msrA1 in Methicillin-Susceptible or -Resistant Staphylococcus aureus

R Pechous, N Ledala, BJ Wilkinson… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Genome-wide transcriptional profiling studies of the response of Staphylococcus aureus to
cell wall-active antibiotics have led to the discovery of a cell wall stress stimulon of genes …

Genomic analysis reveals a point mutation in the two-component sensor gene graS that leads to intermediate vancomycin resistance in clinical Staphylococcus …

BP Howden, TP Stinear, DL Allen… - Antimicrobial agents …, 2008 - Am Soc Microbiol
Methicillin-resistant Staphylococcus aureus (MRSA), once restricted to hospitals, is
spreading rapidly through the wider community. Resistance to vancomycin, the principal …

Identification of the up-and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method

M Kuroda, K Kuwahara-Arai, K Hiramatsu - Biochemical and biophysical …, 2000 - Elsevier
We previously reported the first vancomycin-resistant Staphylococcus aureus (VRSA)
clinical strain, Mu50, whose cell wall is remarkably thickened resulting from the activation of …

Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target

R Zoraghi, RH See, P Axerio-Cilies… - Antimicrobial agents …, 2011 - Am Soc Microbiol
Novel classes of antimicrobials are needed to address the challenge of multidrug-resistant
bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). Using the architecture …

The Role of ArlRS and VraSR in Regulating Ceftaroline Hypersusceptibility in Methicillin-Resistant Staphylococcus aureus

M Villanueva, M Roch, I Lasa, A Renzoni, WL Kelley - Antibiotics, 2021 - mdpi.com
Methicillin-resistant Staphylococcus aureus infections are a global health problem. New
control strategies, including fifth-generation cephalosporins such as ceftaroline, have been …

[HTML][HTML] New insight into transmembrane topology of Staphylococcus aureus histidine kinase AgrC

L Wang, C Quan, W Xiong, X Qu, S Fan… - Biochimica et Biophysica …, 2014 - Elsevier
Staphylococcus aureus accessory gene regulator (agr) locus controls the expression of
virulence factors through a classical two-component signal transduction system that consists …

Chemical Intervention on Staphylococcus aureus Virulence

LL Zhou, CG Yang - Chinese Journal of Chemistry, 2019 - Wiley Online Library
Resistance to conventional antibiotics has raised worldwide attention. Notably, Methicillin‐
resistant Staphylococcus aureus (MRSA) has become one of the most life‐threatening …

[HTML][HTML] Staphylococcus aureus quorum regulator SarA targeted compound, 2-[(Methylamino) methyl] phenol inhibits biofilm and down-regulates virulence genes

P Balamurugan, V Praveen Krishna… - Frontiers in …, 2017 - frontiersin.org
Staphylococcus aureus is a widely acknowledged Gram-positive pathogen for forming
biofilm and virulence gene expressions by quorum sensing (QS), a cell to cell …