Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

A very significant density of adenosine A2A receptors (A2ARs) is present in the striatum,
where they are preferentially localized postsynaptically in striatopallidal medium spiny …

Adenosine, by acting on adenosine A1 and A2A receptors, exerts opposite modulatory roles
on striatal extracellular levels of glutamate and dopamine, with activation of A1 inhibiting …

The striatum is a subcortical area involved in sensorimotor, cognitive and emotional
processes. Adenosine A2A receptors (A2ARs) are highly expressed in the striatum, and their …

In the striatum, adenosine A2A receptors (A2AR) are mainly expressed within the soma and
dendrites of the striatopallidal neuron. A predominant proportion of these striatal …

The dorsal striatum is a key node for many neurobiological processes such as motor activity,
cognitive functions, and affective processes. The proper functioning of striatal neurons relies …

Adenosine and dopamine are two important modulators of glutamatergic neurotransmission
in the striatum. However, conflicting reports exist about the role of adenosine and adenosine …

Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …

Basal ganglia processing results from a balanced activation of direct and indirect striatal
efferent pathways, which are controlled by dopamine D1 and D2 receptors, respectively …

Adenosine A2A receptors (A2ARs) are highly concentrated in the striatum. Two
pharmacological different functional populations of A2ARs have been recently described …