Multidrug resistance has become a problem in the management of tuberculosis, with an
urgent need for research into new drugs as well as the development of efficacious drug …

Some novel 1, 3, 4-thiadiazole [5-8] and 1, 2, 4-triazole [9-12] derivatives carrying amino
acid moiety were synthesized starting from L-methionine. 1, 3, 4-Thiadiazole and 1, 2, 4 …

Eighteen 5-nitrofuran-2-yl derivatives were prepared by reacting 5-nitro-2-furfural with
various (sub) phenyl/pyridyl thiosemicarbazide using microwave irradiation. The compounds …

Sixteen novel 3-nitro-2-(sub)-5, 12-dihydro-5-oxobenzothiazolo [3, 2-a]-1, 8-naphthyridine-6-
carboxylic acids were synthesized from 2, 6-dimethoxynicotinic acid and 2-aminothiophenol …

Due to the emergence of multidrug-resistant and extensively drug-resistant (XDR) strains of
Mycobacterium tuberculosis, new antituberculosis drugs are urgently required to improve …

The comparative activity of five phenothiazines against multidrug-resistant strains of
Mycobacterium tuberculosis (MDRTB) was studied using the Bactec 460 system. The order …

A series of N-[2-(2-furyl)-2-oxoethyl], N-[2-(2-furyl)-2-oxyiminoethyl], N-[2-oxo-2-(2-thienyl)
ethyl] and N-[2-oxyimino-2-(2-thienyl) ethyl] piperazinyl quinolones (1a–h; 2a–h) were …

Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been
synthesized. The compounds were screened for their in vitro anti-bacterial activity using …

Mycobacterium tuberculosis is the etiologic agent of tuberculosis. The demand for new
chemotherapeutics with unique mechanisms of action to treat (multi) resistant strains is an …

From in vivo observations, a majority of M. tuberculosis cells in latently infected individuals
are in a dormant and probably nonculturable state, display little metabolic activity, and are …