Novel therapeutic modalities and drug delivery – erlotinib liposomes modified with galactosylated lipid: in vitro and in vivo investigations

H Xu, C He, Y Liu, J Jiang, T Ma - Artificial cells, nanomedicine …, 2018 - Taylor & Francis
The aim of this study to develop galactosylated erlotinib liposomes for treatment of lung
cancer. The liposomes were prepared by using solvent evaporation method. Various …

[HTML][HTML] Comparative of in-vitro evaluation between erlotinib loaded nanostructured lipid carriers and liposomes against A549 lung cancer cell line

FA Gaballu, S Abbaspour-Ravasjani… - Iranian journal of …, 2019 - ncbi.nlm.nih.gov
Erlotinib (ELT) as a small molecule with poor solubility, poor bioavailability, and instability in
gastrointestinal environment, has been considered as a therapeutic agent for Non-Small …

Development of asolectin-based liposomal formulation for controlled and targeted delivery of erlotinib as a model drug for EGFR monotherapy

S Pardeshi, A Tiwari, U Titame, PK Singh… - Journal of Liposome …, 2022 - Taylor & Francis
The present investigation was envisaged to develop liposomal formulation for efficacious
and targeted delivery of epidermal growth factor receptor (EGFR) inhibitor (erlotinib) against …

Preparation and evaluation of gefitinib containing nanoliposomal formulation for lung cancer therapy

S Rohilla, R Awasthi, M Mehta, DK Chellappan… - BioNanoScience, 2022 - Springer
The present study was aimed to develop and optimize nanoliposomes of gefitinib for
effective tumor targeting. Central composite design was used to study the effect of …

PEGylated polypeptide lipid nanocapsules to enhance the anticancer efficacy of erlotinib in non-small cell lung cancer

J Kim, T Ramasamy, JY Choi, ST Kim, YS Youn… - Colloids and Surfaces B …, 2017 - Elsevier
In this study, a core-shell type polypeptide-based lipid nanocapsule was developed to
enhance anticancer efficacy of erlotinib in non-small cell lung cancers. Mean particle size of …

Role of solid lipid nanoparticles as drug delivery vehicles on the pharmacokinetic variability of Erlotinib HCl

R Rampaka, K Ommi, N Chella - Journal of Drug Delivery Science and …, 2021 - Elsevier
Abstract Background and objectives Erlotinib HCl is approved for the treatment of metastatic
non-small cell lung cancer. Owing to its poor aqueous solubility and presystemic …

[HTML][HTML] Investigation on physicochemical characteristics of a nanoliposome-based system for dual drug delivery

JH Nam, SY Kim, H Seong - Nanoscale research letters, 2018 - Springer
Synergistic effects of multiple drugs with different modes of action are utilized for
combinatorial chemotherapy of intractable cancers. Translation of in vitro synergistic effects …

Arsenic trioxide and Erlotinib loaded in RGD‐modified nanoliposomes for targeted combination delivery to PC3 and PANC‐1 cell lines

F Khosravani, H Mir, A Mirzaei… - Biotechnology and …, 2023 - Wiley Online Library
During the past few years, advances in drag delivery have provided many opportunities in
the treatment of various diseases and cancer. Arsenic trioxide (ATO) and Erlotinib (Erlo) are …

Liposomal form of erlotinib for local inhalation administration and efficiency of its transport to the lungs

J Szabová, O Mišík, J Fučík, K Mrázová… - International Journal of …, 2023 - Elsevier
This contribution is focused on the preparation of a liposomal drug delivery system of
erlotinib resisting the nebulization process that could be used for local treatment of non …

Improved oral bioavailability and therapeutic efficacy of erlotinib through molecular complexation with phospholipid

CP Dora, V Kushwah, SS Katiyar, P Kumar… - International journal of …, 2017 - Elsevier
The current study was aimed to prepare a molecular complex of erlotinib (ERL) with
phospholipid (PC) for enhancement of solubility and thus bioavailability, therapeutic efficacy …