Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

Oxygen homeostasis reflects the constant body requirement to generate energy. Hypoxia
(0.1–1% O2), physioxia or physoxia (∼ 1–13%), and normoxia (∼ 20%) are terms used to …

Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the
negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole …

Highlights•Hypoxia is a prominent feature in inflamed tissues.•The HIF pathway is a potential
therapeutic target in inflammation.•Hydroxylase inhibition is anti-inflammatory in models of …

Hypoxia-inducible factors (HIFs) are oxygen-sensitive transcription factors that allow
adaptation to hypoxic environments. HIFs function in the cellular response to stress …

Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular
transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene …

Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

Since the discovery of hypoxia-inducible factor (HIF), numerous studies on the hypoxia
signaling pathway have been performed. The role of HIF stabilization during hypoxia has …