Abstract Silent Information Regulator 1 (SIRT1), an NAD+-dependent deacetylase,
contributes to the neuroprotective effect. However, intracellular signaling pathways that …

Silent information regulator 1 (SIRT1), an NAD+-dependent deacetylase, is involved in the
regulation of gene transcription, energy metabolism, and cellular aging and has become an …

Traumatic brain injury (TBI) is a serious insult that frequently leads to neurological
dysfunction or death. Silent information regulator family protein 1 (SIRT1), as the founding …

Common environmental pollutants and drugs encountered in everyday life can cause toxic
damage to the body through oxidative stress, inflammatory stimulation, induction of …

Background Sirtuins (Sirt), a family of nicotinamide adenine nucleotide (NAD) dependent
deacetylases, are implicated in energy metabolism and life span. Among the known Sirt …

Excitotoxicity is the presence of excessive glutamate, which is normally taken up by
glutamate transporters on astrocytes. Glutamate transporter 1 (GLT-1) is the major …

Traumatic brain injury (TBI) is a major cause of disability and death in patients who
experience a traumatic injury. Mitochondrial dysfunction is one of the main factors …

Abstract Silent information regulator 2 (Sirtuin2/SIRT2) is a NAD+-dependent deacetylase
that regulates the cellular oxidative stress response. It modulates transcriptional silencing …

Abstract Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide
adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Previous studies have …

Background and Purpose—Sirtuin 1 (SIRT1) is a member of NAD+-dependent protein
deacetylases implicated in a wide range of cellular functions and has beneficial properties in …