Since the discovery of striatal neurons expressing dopamine-synthesizing enzymes,
researchers have attempted to identify their phenotype and functional significance. In this …

In addition to catecholaminergic neurons possessing all the enzymes of catecholamine
synthesis and the specific membrane transporters, neurons partly expressing the …

The mammalian striatum is known to contain non-dopaminergic neurons that express
dopamine (DA)-synthesizing enzymes and produce DA, responsible for the regulation of …

Parkinson's disease (PD) is a progressive neurological disease caused by selective
degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) …

The loss of dopaminergic (DA) neurons in the ventral midbrain is the principal cause of
Parkinson's disease. The search for candidate molecules that promote the genesis and …

Non-dopaminergic neurons expressing individual complementary enzymes dopamine (DA)
synthesis were shown to produce DA in cooperation [Ugrumov, M., Melnikova, V., Ershov, P …

Human-derived neuronal cell lines are progressively being utilized in understanding
neurobiology and preclinical translational research as they are biologically more relevant …

Dopaminergic neurons (DNs) of the nigrostriatal system control the motor function, and their
degeneration leads to the development of Parkinson's disease (PD). A stumbling block in …

Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

The most important component of the pathogenesis of Parkinson's disease is the
degradation of the nigrostriatal dopaminergic system, which is a key link in the regulation of …