Studying the initial molecular mechanisms of the pathogenesis of Parkinson's disease (PD),
primarily in the nigrostriatal dopaminergic system, is one of the priorities in neurology. Of …

Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues
demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's …

The progressive degeneration of dopamine (DA)-melanized neurons of the substantia nigra
pars compacta (SNpc) represents the pathological hallmark of Parkinson's disease (PD) …

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The fight against neurodegenerative diseases, including Parkinson's disease (PD), is
among the global challenges of the 21st century. The low efficiency of therapy is due to the …

The aim of the present work was to verify the hypothesis that non-dopaminergic neurons
expressing individual complementary dopamine synthesis enzymes can perform the co …

In the recent past, the pathogenesis of Parkinson's disease (PD) has evolved from a
neurodegenerative disorder considered entirely sporadic to a disease with an unequivocal …

Parkinson's disease (PD) is a neurodegenerative disorder, which results from the loss of
specific population of neurons, namely the pigmented dopamine secreting neurons of the …

The relatively few dopaminergic neurons in the mammalian brain are mostly located in the
midbrain and regulate many important neural functions, including motor integration …

Dopaminergic (DA) neurons in the midbrain are critically involved in several neurological-
psychiatric illnesses and are specifically lost in Parkinson's disease. The DA neurons are …