Lipid peroxidation occurs in the context of many physiological processes but is greatly
increased in various pathological situations. A consequence of phospholipid peroxidation is …

Oxidized phospholipids, such as the products of the oxidation of 1-palmitoyl-2-arachidonoyl-
sn-glycero-3-phosphocholine by nonenzymatic radical attack, are known to be formed in a …

Glycerophospholipids represent a common class of lipids critically important for integrity of
cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes …

During inflammatory processes biologically active lipid oxidation products accumulate that
modulate the inflammatory process and may determine the fate and outcome of the body's …

Abstract Age-related Macular Degeneration (AMD) is the leading cause of blindness among
the elderly in western societies. While antioxidant micronutrient treatment is available for …

Oxidized phospholipids that result from tissue injury operate as immunomodulatory signals
that, depending on the context, lead to proinflammatory or anti-inflammatory responses. In …

Biologically active oxidized phospholipids can initiate and modulate many of the cellular
events attributed to inflammation leading to atherosclerosis. Produced by enzymatic or non …

Phospholipids are of critical importance in mammalian cell biology, both through providing a
permeability barrier and acting as substrates for synthesis of lipid mediators. Recently …

Accumulating evidence suggests that oxidation-specific epitopes (OSEs) constitute a novel
class of damage-associated molecular patterns (DAMPs) generated during high oxidative …

Oxidants and free radicals are deleterious in many ways, and organisms employ numerous
approaches to block their production or limit their damage. Hydrogen atoms adjacent to …