Lipid peroxidation: physiological levels and dual biological effects

E Niki - Free Radical Biology and Medicine, 2009 - Elsevier
Lipid peroxidation (LPO) has been shown to induce disturbance of membrane organization
and functional loss and modification of proteins and DNA bases, and it has been implicated …

Oxidation‐specific epitopes are important targets of innate immunity

MY Chou, K Hartvigsen, LF Hansen… - Journal of internal …, 2008 - Wiley Online Library
During the oxidation of LDL, a central pathophysiological component of atherogenesis, a
wide variety of chemical and physical changes occur leading to the generation of oxidation …

Bioactive products of phospholipid oxidation: isolation, identification, measurement and activities

G Subbanagounder, AD Watson, JA Berliner - Free Radical Biology and …, 2000 - Elsevier
There is considerable evidence to suggest that oxidation of LDL plays an important role in
atherogenesis. Polyunsaturated fatty acids, a major oxidative target, are present as …

Rethinking oxidized low-density lipoprotein, its role in atherogenesis and the immune responses associated with it.

PX Shaw - Archivum immunologiae et therapiae experimentalis, 2004 - europepmc.org
Atherosclerosis is a chronic inflammatory disease, resulting from hyperlipidemia and a
complex interplay of many environmental, metabolic, and genetic risk factors. The …

Cell signalling by reactive lipid species: new concepts and molecular mechanisms

A Higdon, AR Diers, JY Oh, A Landar… - Biochemical …, 2012 - portlandpress.com
The process of lipid peroxidation is widespread in biology and is mediated through both
enzymatic and non-enzymatic pathways. A significant proportion of the oxidized lipid …

Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils

N Leitinger, TR Tyner, L Oslund… - Proceedings of the …, 1999 - National Acad Sciences
We previously have demonstrated that oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-
phosphorylcholine (OxPAPC), a component of minimally modified low density lipoprotein …

Membrane changes under oxidative stress: the impact of oxidized lipids

R Itri, HC Junqueira, O Mertins, MS Baptista - Biophysical reviews, 2014 - Springer
Studying photosensitized oxidation of unsaturated phospholipids is of importance for
understanding the basic processes underlying photodynamic therapy, photoaging and many …

The regulation of inflammation by oxidized phospholipids

S Freigang - European journal of immunology, 2016 - Wiley Online Library
During inflammation or under conditions of oxidative stress, the polyunsaturated fatty acid
side chains of phospholipids in cellular membranes or lipoproteins can be oxidatively …

Bioactive phospholipid oxidation products

GK Marathe, KA Harrison, RC Murphy… - Free Radical Biology …, 2000 - Elsevier
Oxidation of phospholipids results in chain-shortened fragments and oxygenated derivatives
of polyunsaturated sn-2 fatty acyl residues, generating a myriad of phospholipid products …

[HTML][HTML] Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids: importance of Schiff base formation and Aldol …

P Friedman, S Hörkkö, D Steinberg… - Journal of Biological …, 2002 - ASBMB
The oxidation of low density lipoproteins (LDL) has been correlated with atherogenesis
through a variety of pathways. The process involves nonspecific fragmentation, oxidative …