[HTML][HTML] Convergence of brain transcriptomic and neuroimaging patterns in schizophrenia, bipolar disorder, autism spectrum disorder, and major depressive disorder
Background Psychiatric conditions show overlap in their symptoms, genetics, and
involvement in brain areas and circuits. Structural alterations in the brain have been found to …
involvement in brain areas and circuits. Structural alterations in the brain have been found to …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak… - FOCUS, A Journal …, 2019 - Am Psychiatric Assoc
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology
It is increasingly recognized that multiple psychiatric conditions are underpinned by shared
neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural …
neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural …
Genetic heterogeneity shapes brain connectivity in psychiatry
Background Polygenicity and genetic heterogeneity pose great challenges for studying
psychiatric conditions. Genetically informed approaches have been implemented in …
psychiatric conditions. Genetically informed approaches have been implemented in …
[HTML][HTML] Transcriptomic insight into the polygenic mechanisms underlying psychiatric disorders
Over the past decade, large-scale genetic studies have successfully identified hundreds of
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …
genetic variants robustly associated with risk for psychiatric disorders. However, mechanistic …
Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
Schizophrenia is a prototypical network disorder with widespread brain-morphological
alterations, yet it remains unclear whether these distributed alterations robustly reflect the …
alterations, yet it remains unclear whether these distributed alterations robustly reflect the …
Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank
Major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BP) are
common, disabling and heritable psychiatric diseases with a complex overlapping polygenic …
common, disabling and heritable psychiatric diseases with a complex overlapping polygenic …
Cross-disorder analysis of brain structural abnormalities in six major psychiatric disorders: a secondary analysis of mega-and meta-analytical findings from the …
N Opel, J Goltermann, M Hermesdorf, K Berger… - Biological …, 2020 - Elsevier
Background Neuroimaging studies have consistently reported similar brain structural
abnormalities across different psychiatric disorders. Yet, the extent and regional distribution …
abnormalities across different psychiatric disorders. Yet, the extent and regional distribution …
Novel gene-brain structure relationships in psychotic disorder revealed using parallel independent component analyses
Background Schizophrenia, schizoaffective disorder, and psychotic bipolar disorder overlap
with regard to symptoms, structural and functional brain abnormalities, and genetic risk …
with regard to symptoms, structural and functional brain abnormalities, and genetic risk …
Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders
Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing
multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations …
multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations …