The unconventional role of Akt1 in the advanced cancers and in diabetes-promoted carcinogenesis
Decades of research have elucidated the critical role of Akt isoforms in cancer as pro-
tumorigenic and metastatic regulators through their specific effects on the cancer cells, tumor …
tumorigenic and metastatic regulators through their specific effects on the cancer cells, tumor …
AKT signaling in regulating angiogenesis
BH Jiang, LZ Liu - Current cancer drug targets, 2008 - ingentaconnect.com
AKT is a central signaling molecule in regulating cell survival, proliferation, tumor growth
and angiogenesis. Upstream components of AKT signaling pathway such as PI3K, PTEN …
and angiogenesis. Upstream components of AKT signaling pathway such as PI3K, PTEN …
Deregulation of the Akt pathway in human cancer
E Tokunaga, E Oki, A Egashira… - Current cancer drug …, 2008 - ingentaconnect.com
Akt (protein kinase B) is a serine/threonine kinase which is a central regulator of widely
divergent cellular processes including proliferation, differentiation, migration, survival and …
divergent cellular processes including proliferation, differentiation, migration, survival and …
[HTML][HTML] Significance of AKT in gastric cancer
T Sasaki, H Kuniyasu - international journal of oncology, 2014 - spandidos-publications.com
AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for
various pro‑proliferation and bioactive substances as well as the extracellular matrix …
various pro‑proliferation and bioactive substances as well as the extracellular matrix …
Akt signaling and cancer: surviving but not moving on
A Toker, M Yoeli-Lerner - Cancer research, 2006 - AACR
The frequent deregulation of the phosphoinositide 3-kinase/Akt survival signaling pathway
in cancer has prompted significant interest in blocking this pathway to treat cancer. Recently …
in cancer has prompted significant interest in blocking this pathway to treat cancer. Recently …
Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells
X Liu, Y Shi, EKH Han, Z Chen, SH Rosenberg… - Neoplasia, 2001 - Elsevier
The serine/threonine kinases, Akti/PKBα, Akt2/PKBβ, and Akt3/PKBγ, play a critical role in
preventing cancer cells from undergoing apoptosis. However, the function of individual Akt …
preventing cancer cells from undergoing apoptosis. However, the function of individual Akt …
Specific targeting of Akt kinase isoforms: Taking the precise path for prevention and treatment of cancer
Akt kinase is a serine threonine kinase that exists in three isoforms, located in different
chromosomes and has distinct sites of expression which orchestrates diverse cellular …
chromosomes and has distinct sites of expression which orchestrates diverse cellular …
[HTML][HTML] Akt: a key transducer in cancer
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
Functional specificity of Akt isoforms in cancer progression
Akt/PKB kinases are central mediators of cell homeostasis. There are three highly
homologous Akt isoforms, Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ. Hyperactivation of Akt …
homologous Akt isoforms, Akt1/PKBα, Akt2/PKBβ and Akt3/PKBγ. Hyperactivation of Akt …
Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery
AKT (also known as PKB) plays a central role in a variety of cellular processes including cell
growth, motility and survival in both normal and tumor cells. The AKT pathway is also …
growth, motility and survival in both normal and tumor cells. The AKT pathway is also …