Dendritic cells: a critical player in cancer therapy?

AK Palucka, H Ueno, J Fay… - Journal of …, 2008 - journals.lww.com
Cancer immunotherapy seeks to mobilize a patient's immune system for therapeutic benefit.
It can be passive, that is, transfer of immune effector cells (T cells) or proteins (antibodies), or …

Dendritic cells: are they clinically relevant?

K Palucka, H Ueno, L Roberts, J Fay… - The Cancer …, 2010 - journals.lww.com
Cancer vaccines have undergone a renaissance because of recent clinical trials showing
promising immunologic data and some clinical benefit to patients. Current trials exploiting …

Optimizing dendritic cell-based immunotherapy for cancer

H Zhong, MR Shurin, B Han - Expert review of vaccines, 2007 - Taylor & Francis
Dendritic cells (DCs) are the most powerful professional antigen-presenting cells and are
unique in their capability to initiate, maintain and regulate the intensity of primary immune …

Trial watch: Dendritic cell-based interventions for cancer therapy

L Galluzzi, L Senovilla, E Vacchelli, A Eggermont… - …, 2012 - Taylor & Francis
Dendritic cells (DCs) occupy a central position in the immune system, orchestrating a wide
repertoire of responses that span from the development of self-tolerance to the elicitation of …

Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

H Xu, X Cao - Frontiers of medicine, 2011 - Springer
According to the GLOBOCAN reports, there were about 12.7 million cancer cases and 7.6
million cancer deaths in 2008, and the cancer burden continues to increase worldwide [1]. At …

Dendritic cell-based vaccines for the therapy of experimental tumors

E Pajtasz-Piasecka, M Indrova - Immunotherapy, 2010 - Taylor & Francis
Dendritic cells (DCs) are believed to be the most potent antigen-presenting cells able to link
the innate and adaptive immune systems. Many studies have focused on different …

Personalized dendritic cell-based tumor immunotherapy

N Janikashvili, N Larmonier, E Katsanis - Immunotherapy, 2010 - Taylor & Francis
Advances in the understanding of the immunoregulatory functions of dendritic cells (DCs) in
animal models and humans have led to their exploitation as anticancer vaccines. Although …

Modulation of antitumor responses by dendritic cells

J Vieweg, A Jackson - Springer seminars in immunopathology, 2005 - Springer
The discovery that dendritic cells (DC) play a key role in regulating antitumor immunity has
prompted considerable efforts in developing DC-based cancer vaccines for use in clinical …

Dendritic cell-based therapeutic cancer vaccines: what we have and what we need

P Kalinski, J Urban, R Narang, E Berk… - Future …, 2009 - Taylor & Francis
Therapeutic cancer vaccines rely on the immune system to eliminate tumor cells. In contrast
to chemotherapy or passive (adoptive) immunotherapies with antibodies or ex vivo …

Dendritic cell-based cancer immunotherapy: Achievements and novel concepts

KF Bol, G Schreibelt, EHJG Aarntzen… - … Paradigms, practice and …, 2013 - Springer
Dendritic cells (DCs) are the most potent professional antigen-presenting cells of the
immune system. They acquire and process antigen and migrate to the lymphoid organs …