Research using animal models of asthma is currently dominated by mouse models. This has
been driven by the comprehensive knowledge on inflammatory and immune reactions in …

Asthma is characterized by chronic lower airway inflammation that results in airway
remodeling, which can lead to a permanent decrease in lung function. The pathophysiology …

In vivo animal models can offer valuable information on several aspects of asthma
pathogenesis and treatment. The mouse is increasingly used in these models, mainly …

Animal models of asthma are a tool that allows studies to be conducted in the setting of an
intact immune and respiratory system. These models have highlighted the importance of T …

Asthma is a complex syndrome with many clinical phenotypes in children and adults.
Despite the rapidly increasing prevalence, clinical investigation and epidemiological studies …

Mouse models are critical for delineating the mechanisms that underlie asthma
pathogenesis and developing new treatments. In this chapter we describe four different …

The diversity of asthma phenotypes increases its complexity. Animal models represent a
useful tool to elucidate the pathophysiological mechanisms involved in both allergic and …

Human asthma is on the rise worldwide. The necessity to develop effective treatments
against it requires an organized effort which covers every aspect of the disease from the …

Clinical studies in asthma are not able to clear up all aspects of disease pathophysiology.
Animal models have been developed to better understand these mechanisms and to …

Publisher Summary Animal models, including guinea pigs, monkeys, rats, and mice are
used to study the pathogenesis of asthma. Mouse models of allergic lung disease are …