Intracerebral hemorrhage (ICH) is a major cause of stroke, with high mortality and morbidity.
There is no effective pharmacological therapy for ICH. Previous studies have indicated that …

Background and Purpose—Inflammatory response plays a critical role in propagating tissue
damage after focal cerebral ischemia. CXCL12 is a key chemokine for leukocyte recruitment …

CXC chemokine receptor type 4 (CXCR4) is a receptor for a pleiotropic chemokine CXCL12.
Previous studies have shown that the acute administration of the CXCR4 antagonist …

This study sought to identify potential targets for acute stroke therapy that can be exploited
pharmacologically beyond the current 4.5 h time limit for clinical administration of …

OBJECTIVE Ischemic stroke may result from transient or permanent reductions of regional
cerebral blood flow. Polymorphonuclear neutrophils have been described as the earliest …

Spinal cord ischemia-reperfusion injury (SCII) remains an unresolved complication and its
underlying mechanism has not been fully elucidated. In this study, we studied the role of …

Inflammation-related cerebral damage mediated by infiltrating neutrophils following
reperfusion plays a role in reperfusion-induced brain damage subsequent to a stroke event …

ABSTRACT Primary Objective: Chemokine CC motif ligand 2 (CCL2) plays a critical role in
inflammation-related diseases in the central nervous system (CNS). However, the role of …

Abstract Background Chemokine (C-X3-C motif) ligand 1 (CX3CL1)/CX3C chemokine
receptor 1 (CX3CR1) signaling is important in modulating the communication between …

Leukocyte infiltration is viewed as a pharmacological target in cerebral ischemia. We
previously reported that reparixin, a CXCL8 receptor blocker that inhibits neutrophil …