Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
Mapping the genetic architecture of cortical morphology through neuroimaging: progress and perspectives
D van der Meer, T Kaufmann - Translational Psychiatry, 2022 - nature.com
Cortical morphology is a key determinant of cognitive ability and mental health. Its
development is a highly intricate process spanning decades, involving the coordinated …
development is a highly intricate process spanning decades, involving the coordinated …
Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area
The thickness of the cerebral cortical sheet and its surface area are highly heritable traits
thought to have largely distinct polygenic architectures. Despite large-scale efforts, the …
thought to have largely distinct polygenic architectures. Despite large-scale efforts, the …
The genetic architecture of the human cerebral cortex
KL Grasby, N Jahanshad, JN Painter, L Colodro-Conde… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …
Variations in human cortical surface area and thickness are associated with neurological …
Genetic complexity of cortical structure: differences in genetic and environmental factors influencing cortical surface area and thickness
Quantifying the genetic architecture of the cerebral cortex is necessary for understanding
disease and changes to the brain across the lifespan. Prior work shows that both surface …
disease and changes to the brain across the lifespan. Prior work shows that both surface …
Genetic map of regional sulcal morphology in the human brain from UK biobank data
Genetic associations with macroscopic brain structure can provide insights into brain
function and disease. However, specific associations with measures of local brain folding …
function and disease. However, specific associations with measures of local brain folding …
Cell-specific gene-expression profiles and cortical thickness in the human brain
Neurobiological underpinnings of cortical thickness in the human brain are largely unknown.
Here we use cell-type-specific gene markers to evaluate the contribution of 9 neural cell …
Here we use cell-type-specific gene markers to evaluate the contribution of 9 neural cell …
Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis
Recent work in imaging genetics suggests high levels of genetic overlap within cortical
regions for cortical thickness (CT) and surface area (SA). We model this multivariate system …
regions for cortical thickness (CT) and surface area (SA). We model this multivariate system …
A unified framework for association and prediction from vertex‐wise grey‐matter structure
The recent availability of large‐scale neuroimaging cohorts facilitates deeper
characterisation of the relationship between phenotypic and brain architecture variation in …
characterisation of the relationship between phenotypic and brain architecture variation in …