Coronary heart disease is the most common cause of heart failure. Its prevalence has
increased mainly owing to the improved survival of patients after acute myocardial infarction …

Compared with heart failure (HF) care 20 to 30 years ago, there has been tremendous
advancement in therapy for ambulatory HF with reduced ejection fraction with the use of …

The optimal management of systolic heart failure includes combination therapy to influence
myocardial remodelling favourably by affecting neurohormonal activation and underlying …

Heart failure is unique among the major cardiovascular disorders in that it alone is
increasing in prevalence while there has been a striking decrease in other conditions. Some …

Heart failure, whether acute or chronic, remains a major health care crisis affecting almost 6
million Americans and over 23 million people worldwide. Roughly half of those affected will …

Abstract Purpose of Review Ischemic cardiomyopathy refers to systolic left ventricular
dysfunction in the setting of obstructive coronary artery disease and represents the most …

Heart failure (HF) treatment has progressed considerably over the last two decades.
Whereas before that time only a symptomatic approach was possible, subsequent large …

The SMILE-4 study showed that in patients with left ventricular dysfunction (LVD) after acute
myocardial infarction, early treatment with zofenopril plus acetyl salicylic acid is associated …

Heart failure is a major public health problem. Heart failure with preserved systolic function
(HF-PSF) is a common form, which is difficult to diagnose. Results of recent studies show …

The failure to translate novel cardioprotective therapies tested in pre-clinical studies into the
clinical setting for patient benefit can be attributed to a number of factors at different stages of …