Mammalian oocytes develop and mature in a mutually dependent relationship with
surrounding cumulus cells. The oocyte actively regulates cumulus cell differentiation and …

Oocyte-derived bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9
(GDF9) are key regulators of follicular development. Here we show that these factors control …

Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of
what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular …

抄録 卵丘細胞は, 卵子を直接覆う細胞層を形成し, その性質は卵子分泌因子により制御されている.
一方, 卵子もまた卵丘細胞からギャップジャンクションを介して送られるグルコース代謝物に …

Coordination of extra-and intrafollicular signals is required for the development of ovarian
follicles and for the production of functional oocytes. Oocytes play an active role in this …

Oocyte maturation is a key process during which the female germ cell undergoes
resumption of meiosis and completes its preparation for embryonic development including …

Mammalian follicles are constituted of a complex structure composed of several layers of
granulosa cells surrounding the oocyte and of theca cells that reside beneath its basement …

Oocyte–cumulus cell interaction is essential for oocyte maturation and competence. The
bidirectional crosstalk network mediated by gap junctions is fundamental for the metabolic …

Bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) are
oocyte-specific growth factors that appear to play key roles in granulosa cell development …

Intercellular communication between oocytes and granulosa cells is essential for normal
follicular differentiation and oocyte development. Subtraction hybridization was used to …