β-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease: a new paradigm for prognosis and therapy?

GD Femminella, G Rengo, G Pagano… - Journal of …, 2013 - content.iospress.com
Alzheimer's disease (AD) is a devastating form of dementia that imposes a severe burden on
health systems and society. Although several aspects of AD pathogenesis have been …

Roles of β-adrenergic receptors in Alzheimer's disease: Implications for novel therapeutics

JT Yu, ND Wang, T Ma, H Jiang, J Guan, L Tan - Brain Research Bulletin, 2011 - Elsevier
Alzheimer's disease (AD), the most common cause of age-related dementia, is a progressive
neurodegenerative disorder with an enormous unmet medical need. In recent years, several …

The role of beta-adrenergic receptor blockers in Alzheimer's disease: Potential genetic and cellular signaling mechanisms

K Lương, LTH Nguyễn - American Journal of Alzheimer's …, 2013 - journals.sagepub.com
According to genetic studies, Alzheimer's disease (AD) is linked to beta-adrenergic receptor
blockade through numerous factors, including human leukocyte antigen genes, the renin …

Administration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease

C Branca, EV Wisely, LK Hartman, A Caccamo… - Neurobiology of …, 2014 - Elsevier
Currently, there are no available approaches to cure or slow down the progression of
Alzheimer's disease (AD), which is characterized by the accumulation of extracellular …

The β‐adrenergic hypothesis of synaptic and microglial impairment in Alzheimer's disease

S Li - Journal of Neurochemistry, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease originating partly from
amyloid β protein‐induced synaptic failure. As damaging of noradrenergic neurons in the …

[HTML][HTML] Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial β2 adrenergic receptors

L Le, AM Feidler, H Li, K Kara-Pabani, C Lamantia… - bioRxiv, 2023 - ncbi.nlm.nih.gov
In Alzheimer's disease (AD) pathophysiology, plaque and tangle accumulation trigger an
inflammatory response that mounts positive feed-back loops between inflammation and …

[HTML][HTML] Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model

M Tournissac, TM Vu, N Vrabic, C Hozer… - Alzheimer's Research & …, 2021 - Springer
Background Old age, the most important risk factor for Alzheimer's disease (AD), is
associated with thermoregulatory deficits. Brown adipose tissue (BAT) is the main …

Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial …

PM Ardestani, AK Evans, B Yi, T Nguyen, L Coutellier… - …, 2017 - Elsevier
Degeneration of noradrenergic neurons occurs at an early stage of Alzheimer's Disease
(AD). The noradrenergic system regulates arousal and learning and memory, and has been …

Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's

MJ Bullido, MC Ramos, A Ruiz-Gómez, AS Tutor… - Neurobiology of …, 2004 - Elsevier
To investigate the potential involvement of adrenergic signaling in Alzheimer's disease (AD)
pathogenesis, we performed genetic and functional studies of genes initiating the cascade …

Adrenergic drugs blockers or enhancers for cognitive decline? What to choose for Alzheimer's disease patients?

GD Femminella, D Leosco, N Ferrara… - CNS & Neurological …, 2016 - ingentaconnect.com
The adrenergic system has an important role in normal central nervous system function as
well as in brain disease. The locus coeruleus, the main source of norepinephrine in brain, is …