A complex network of RNA transcripts is generated from eukaryotic genomes, many of which
are processed in unexpected ways. Here, we highlight how premature transcription …

Cellular homeostasis requires transcriptional outputs to be coordinated, and many events
post-transcription initiation can dictate the levels and functions of mature transcripts. To …

The metazoan-specific Integrator complex catalyzes 3′ end processing of small nuclear
RNAs (snRNAs) and premature termination that attenuates the transcription of many protein …

Termination of RNA polymerase II (RNAPII) transcription in metazoans relies largely on the
cleavage and polyadenylation (CPA) and integrator (INT) complexes originally found to act …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

Transcription termination of messenger RNA (mRNA) is normally achieved by
polyadenylation followed by Rat1p-dependent 5′-3′ exoribonuleolytic degradation of the …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

Integrator regulates the 3′-end processing and termination of multiple classes of
noncoding RNAs. Depletion of INTS11, the catalytic subunit of Integrator, or ectopic …

The concept of early termination as an important means of transcriptional control has long
been established. Even so, its role in metazoan gene expression is underappreciated …

Transcriptional termination is an important yet incompletely understood aspect of gene
expression. Proudfoot, Jopling and colleagues now identify a new Microprocessor-mediated …